SETD1A, a gene associated with schizophrenia, stunts the growth and branching of dendrites and reduces the number of dendritic spines. Reinstating the normal expression of SETD1A in mouse models restored working memory function.
A new study reports the larger the growth of areas associated with thinking in the cortex, the slower the growth of regions associated with emotional, sensory and motor skills.
Researchers reveal the role the cerebellum plays in helping to control the brain's reward system. The researchers identified a direct connection from the cerebellum to the ventral tegmental area. The study may shed new light on neural networks associated with social dysfunction.
Analysis of over 2,000 brain scans revealed evidence of highly reproducible sex differences in the volume of different regions of the brain. On average, females had greater cortical volume in the medial and lateral prefrontal cortex, orbitofrontal cortex, superior temporal cortex, and lateral parietal cortex. Males had increased volume in the ventral temporal and occipital brain regions. Gene expression data suggest the potential role of sex chromosomes that contribute to the differences.
The formation of prefrontal cortex dendritic spine formation sustains the remission of depressive related symptoms and behaviors following ketamine treatment by restoring lost spines.
··5 min read
A new machine-learning algorithm that analyzes EEG data can identify reliable and robust neural signatures associated with antidepressant treatment response.
Using CRISPR to alter the expression of four schizophrenia implicated genes which harbor expression quantitative trait loci, researchers were able to mirror gene expression changes seen in postmortem brains of those suffering from three mental health disorders.
Using fMRI to examine the brains of children while resting, researchers discover anhedonia is associated with hyperconnectivity between the cingulo-opercular network and ventral striatum.
A new study reports estrogen fluctuations can alter brain circuit activation in women with a variant of a specific gene.
A new study in Scientific Reports finds evidence from MRI scans suggests Neanderthal derived genetic variations affect how the brains of modern humans work. Findings may shed light on specific deficits seen in ASD and schizophrenia, researchers believe.
Researchers have identified a link between paternally inherited variants in some noncoding segments of genes and an increased autism risk in subsequent offspring.