New research discovers an early step in how the brain's inhibitory cells get excited. Erbin, a protein critical to brain development, is also crucial for the excitement of inhibitory cells.
A study shows social isolation during early life prevents the cells that make up the brain's white matter from maturing and producing the right amount of myelin, the fatty "insulation" on nerve fibers that helps them transmit long-distance messages within the brain.
When elevated levels of neuregulin-1, a gene associated with schizophrenia, are returned to normal, the symptoms of the illness disappear.
Researchers reveal the Bace1 protein, well known for its role in Alzheimer's disease, controls spindle development in muscles and leads to impaired movement when absent.