Mice lacking the autism-associated SHANK3 gene were more sensitive to sensation, including touch. The mice also had overactive excitatory neurons in the somatosensory cortex, which may account for sensory hypersensitivity.
Mouse study pinpoints the precise location in the brain where distracting stimuli are blocked, allowing for concentration on specific tasks. The findings could have implications for the treatment of ADHD and schizophrenia.
Researchers have created detailed 3D models of pyramidal cells from the neocortex using anatomical data from human cells.
H3 acetylation of basal neural precursor cells may have been an important factor in the evolution of the human neocortex.
Researchers have identified a new mechanism controlling the migration of neurons during brain development.
Researchers discover a new phase of synaptic development. The finding could lead to a better understanding of how learning and memory occur.
Researchers have compiled a new, highly detailed 3D brain map that captures the shapes and activity of neurons in the visual neocortex of mice. The map is freely available for neuroscience researchers and artificial intelligence specialists to utilize.
Study reveals a new role for serotonin in the development of the human neocortex. Serotonin acts cell-extrinsically as a growth factor for basal progenitors in the developing neocortex. Researchers report placenta-driven serotonin likely contributed to the evolutionary expansion of the neocortex in humans.