Common green apple flavorant farnesene enhances nicotine reward in mouse models. The flavorant is also rewarding on its own. Researchers say with or without nicotine, flavored vapes, especially those containing farnesene, pose potential neurological risks, including addiction.
Researchers report alpha 7 nicotinic acetylcholine receptors enhance communication between the hippocampus and frontal cortex, where as a4b7 nicotinic receptors decrease the communication. The findings may have implications for the way stimulation of acetylcholine can be used to treat dementia.