Brain scans of people under the influence of the psilocybin, the active ingredient in magic mushrooms, have given scientists the...
Researchers report repeated social defeat stress activates microglia in the medial prefrontal cortex, triggering inflammation related cytokines. This leads to impaired neural responses in the mPFC, resulting in depressive behavior.
Novel experiences dampen previous memory representations in the hippocampus and prefrontal cortex, facilitating flexible strategy encoding in mice.
As we age, slow brain waves during non-REM sleep fail to time contact with sleep spindles efficiently, leading to a lessened ability to form new memories correctly, a new study reports.
By manipulating the activity of a group of neurons in the medial prefrontal cortex, researchers were able to enhance attention in mice.
Researchers report rats exposed to phthalates, both while in the womb and through lactation, had fewer neurons and synapses than peers who were not exposed to the plasticizing chemicals. Additionally, the phthalate exposed rats showed deficits in cognitive flexibility.
A new study reports adolescent male mice fed with a diet lacking Omega-3 fatty acids performed worse on memory tests and showed increased anxiety during adulthood.
Researchers have discovered a key molecule that appears to reduce anxiety in male mice, but not females.
A new study in mice reveals a possible link between the use of SSRI antidepressants during pregnancy and an increased risk of autism-like symptoms in offspring. Offspring exposed to fluoxetine (Prozac) in utero were more likely to exhibit impaired neurotransmission caused by an overactive serotonin receptor in the prefrontal cortex, an area of the brain implicated in modulating social behaviors. However, treating the mice with a compound that blocks the receptor alleviated the behavioral problems and improved working memory.
S1PR3, a receptor found on the surface of brain cells, may play a key role in stress resilience. Veterans with severe PTSD symptoms had lower levels of the S1PR3 protein in their blood than peers without the disorder.