Long term outcome data of patients with treatment-resistant depression found subcallosal cingulate deep brain stimulation (SCC DBS) was both effective at relieving symptoms and safe.
Long non-coding RNAs (lncRNAs) are significantly altered in depression in both sex and brain site-specific manners. The LINC00473 gene is downregulated in the prefrontal cortex of depressed females, but not males. Findings reveal the role of LINC00473 in sex-specific depression and may explain why females are more vulnerable to depressive symptoms than males.
Reducing H3Q5dop in rat models of cocaine withdrawal significantly reversed cocaine mediated gene expression changes and reduced cocaine-seeking behaviors.
Researchers have identified a bio-chemical circuit that supports neuron-microglia communication. When neurons are active, they release ATP. Microglia sense extracellular ATP and the compound draws the immune cell toward the neuron.
The delicate balance between learning new behaviors and expressing old habits is controlled by two different populations of neurons in the dorsolateral striatum.
Study reveals how the brain utilizes forward-thinking when we try to influence others or gain social control.
A series of ketamine infusions reduced PTSD symptoms by up to 30% from baseline compared to treatment with midazolam, which reduced symptoms by 20% over the same period. Ketamine treatment significantly reduced three of four PTSD associated symptoms, including intrusive thoughts, avoidance, and negative alterations in cognition and mood.
Social isolation experienced during childhood has an impact on adult brain function and behavior. Following two weeks of social isolation immediately following weaning in male mice, researchers noticed a failure in activation of medial prefrontal cortex neurons projecting to the posterior paraventricular thalamus during social exposure in adulthood. Findings suggest medial prefrontal cortex neurons required for sociability are profoundly affected by social isolation at a young age.
Using data from RNA sequencing, researchers have identified three molecular subtypes of Alzheimer's disease.
Ezogabine, a drug that opens up the KCNQ2/3 type potassium channel, significantly improved symptoms of depression and anhedonia.
According to a new study, cocaine has the most potent effects on the female brain when estrogen levels are at their highest.
Short period of parental sexual contact prior to pregnancy increases offspring risk of schizophrenia
Study reports children born to couples who have been in relationships for three years or less may have an increased risk of schizophrenia.
