Motor system neurons not only control movement, they also incite action.
Study links motor neurons' large cell size and supporting structures with genes that underly vulnerability to degeneration associated with ALS.
Findings could lead to better understanding of neurodevelopmental and neurological disorders, such as autism and epilepsy.
UC Berkeley researchers report they have successfully used CRISPR-Cas9 gene editing to delay symptoms and extend lifespan in mouse models of ALS.
Researchers have developed a new model to study neurodegenerative diseases which affect motor neurons, such as ALS.
Researchers have identified a gene network that regulates the development of motor neurons during embryonic development.
The TBK1 gene regulates the disease progression of ALS in mouse models of the neurodegenerative disease. Loss of the TBK1 gene in motor neurons increases SOD1 aggregation and accelerates the onset of the disease.
Researchers have identified a transport defect in models of familial ALS which leads to the accumulation of damaged components.
Researchers provide new insights into the role of UBQLN2 in removing toxic protein clumps.
Changes in gene expression help researchers identify ALS associated pathways and establish the key drivers of motor neuron degeneration in the disease.
Researchers devise a new approach to systematically identifying individual classes of neurons in the spinal cord.
Some neurons have the ability to detect and compensate for neighboring neurons, while others do not. The findings shed new light on synaptic plasticity.
