Motor system neurons not only control movement, they also incite action.
Study links motor neurons' large cell size and supporting structures with genes that underly vulnerability to degeneration associated with ALS.
Findings could lead to better understanding of neurodevelopmental and neurological disorders, such as autism and epilepsy.
Researchers have developed a new model to study neurodegenerative diseases which affect motor neurons, such as ALS.
The TBK1 gene regulates the disease progression of ALS in mouse models of the neurodegenerative disease. Loss of the TBK1 gene in motor neurons increases SOD1 aggregation and accelerates the onset of the disease.
Some neurons have the ability to detect and compensate for neighboring neurons, while others do not. The findings shed new light on synaptic plasticity.