Brain organoids, or mini-brains, created from human stem cells appear to develop in much the same way as a human brain. The organoids follow an internal clock that guides their maturation in sync with the timeline for human brain development.
Researchers have developed a new method of reducing the time it takes to grow mini brain models in the lab. This may accelerate research into diseases and injury that affect the nervous system.
Newly developed brain organoids grown from stem cells showed organized waves of neural activity similar to that seen in living human brains.
Researchers recreated the damage seen in frontotemporal dementia in brain organoid models. The study reveals an experimental drug designed to treat Crohn's disease may help prevent neuron death associated with FTD.
Researchers used hPSCs to grow an organoid that produces inhibitory neurons and plays a critical role in the early development of the cortex.
Machine learning is unable to tell the difference in brain activity between a lab-grown mini-brain and that of a preterm infant who has reached full-term.
Researchers have confirmed a key way in which the Zika virus causes damage to fetal brains.
Brain organoids can be used to study molecular mechanisms that drive brain aging and neurodegenerative disorders. The mini-brains allow for the testing of molecules that could become potential therapeutic treatment options for neurodegenerative diseases.