Penn Medicine research presented today at the 2012 Alzheimer's Association International Conference shows that an anti-tau treatment called epithilone D (EpoD) was effective in preventing and intervening the progress of Alzheimer's disease in animal models, improving neuron function and cognition, as well as decreasing tau pathology.
The model of microtubule assembly that most people accept shows the individual subunits, dimers of the protein tubulin, just adding to the grow cylinder. But another model indicates that tubulin dimmers first form an open sheet structure that later closes into the cylinder. Xing and his team concluded that their computational study of the models indicate that the second model should be seriously considered for further testing.
New research could advance understanding of how brain cell tubes are modified under normal and disease conditions.
A new study reports on the basic structural organization of a molecular motor which performs critical functions within cells.
Epothilone, a cancer drug, appears to be effective in reducing scar tissue formation in spinal cord injuries and stimulating neuroregeneration, a new study reports.
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Researchers have identified a thick band of microtubules within retinal neurons which help provide the energy required for visual processing.
A new study investigates how neurons get their branching shapes.
Study highlights the neuroprotective potential of SKIP.