New findings reveal phagocytes do not fully mature until after birth, contradicting previous assumptions that they mature during embryonic development.
Tau-tangles trigger the inflammatory activation of microglia via the NF-κB pathway. Inhibiting the microglia NF-κB signaling pulled the immune cells out of their inflammatory state and reversed learning and memory problems in tau-based Alzheimer's mouse models.
Microglia dysfunction in those who experienced early life adversity prompts an aberrant stress response during adulthood that may be linked to mental illness.
A molecular process caused by the TREM2 gene mutation in the brain's microglia increases the risk of Alzheimer's disease, a new study reports.
Niaspan, an FDA-approved drug, limits disease progression in lab models of Alzheimer's disease.
A new study in mice finds microglia help neurons grow synapses critical for cognitive function.
Infection with the SARS_CoV-2 virus causes dials down the action of olfactory receptors, resulting in smell loss associated with COVID-19.