Exposure to everyday stressors may result in impairments in endothelial function for patients with major depressive disorder. The findings reveal a possible reason for the association between stress, depression and an increased risk of cardiovascular disease.
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An auditory-based machine learning algorithm was able to identify children diagnosed with depression and anxiety with 80% accuracy after analyzing recordings of their speech. The algorithm identified eight audio features that signify a higher risk of depression. Of these, a lower pitch of voice, repeatable speech inflections and a higher pitch response to surprise stimuli, were more indicative of depression. Researchers hope to develop a smartphone app that records and analyzes speech immediately, helping to better detect children at risk of internalizing disorders.
Adding exercise as a treatment for patients in psychiatric care facilities has positive benefits and is proving to be more effective than medications or psychotherapy alone. Exercise helps reduce mental health disorder symptoms such as anxiety, depression, anger and psychomotor agitation. Researchers say exercise also helps to develop a more balanced and integrated sense of self for those with mental health disorders.
A cluster of epigenetic marks in an enhancer at IGF2 could enhance dopamine synthesis associated with psychosis in schizophrenia and bipolar disorder. The findings may help in devising more effective treatments and screening strategies for both disorders.
While it is well-known antidepressants are effective at treating those with depression, a new study reports the medications may be beneficial as a preventative measure for those with a risk factor for depressive disorders.
Mice with a genetic mutation linked to severe depression had impaired ability for neurons in the gut and brain to create serotonin. The reduction of serotonin in the gut led to a deterioration in the gut's lining, slowing the movement of contents through the GI tract and resulting in constipation. However, treatment with 5-HTP increased neurogenesis in the gut, restoring normal function.
Lower socioeconomic status is associated with a higher risk of psychological distress. The increase in psychological distress is, in turn, associated with higher levels of emotional eating and obesity risks.
Study reports regular, vigorous exercise helps to protect males against depressive symptoms, while in women, no levels of physical activity had a significant impact on depression.
Men with alcohol use disorder have diminished brain activity in areas associated with emotional processing, memory and social processing, compared to women with AUD. The findings may lead to gender-specific treatments to help relieve addition to alcohol.
Ketamine, an anesthetics which has been commonly used as an illicit party drug, is helping people overcome depression. The drug works rapidly and provides lasting relief from depressive symptoms for weeks after exposure. Researchers are examining how ketamine works in the brain to help positively influence behavior in those with mood disorders.
Researchers have identified a brain circuit that drives physical response to emotional stress. The circuit begins in the dorsal peduncular cortex and dorsal tenia tecta, before sending signals to the hypothalamus. The findings could help with the development of treatments for panic disorders and PTSD.
A mechanism that links exposure to high-fat diets in mice to changes in hypothalamic function which leads to depression has been identified. Saturated fatty acids enter the brain via the bloodstream, where they accumulate and affect key signaling pathways associated with the development of depression.