In mice, natural melatonin is linked to a pre-hibernation state, allowing for a slower metabolism and survival when food is scarce or the temperature is too cold.
People with myopia appear to have delayed circadian rhythms and lower production of melatonin in the brain compared to those without the visual problem.
Melatonin produced in the lungs acts as a barrier defense against SARS-CoV-2, the virus that causes COVID-19, by blocking the expression of genes that encode proteins in cells acting as viral entry points.
Melatonin and its metabolites promote long-term memory and protect against cognitive decline in mice.
Normal sleep in mice is reliant upon bacteria that help produce neurotransmitters, such as serotonin, in the gut.
In worms, melatonin promotes sleep by activating the BK channel through the MT1 receptor.
Researchers identified a specific neural network that positively responds to melatonin following concussion in children. Results suggest melatonin may help compensate for normal brain function that has been interrupted due to injury caused by concussion and helps prevent sleep disturbances.
The chances of having asthma are three times higher in teenagers who go to bed late at night compared to those who sleep earlier. The risk of allergic rhinitis is two times higher for late sleepers. Researchers say they can not be certain that staying up late is a cause for asthma, however, they note melatonin is often out of sync in late sleepers, and that could be an influential factor in the allergic response.
Researchers identified molecules that can modulate circadian rhythms by binding to the MT1 melatonin receptor in the hypothalamus.
Chronobiologists warn changing to daylight savings can have serious effects on both brain and general health. The change in time during spring was linked to a 24% increase in severe cardiovascular events in women. Researchers also noted the sudden change in time alters circadian rhythms, reduces the production of natural melatonin, impacts cognitive function, and may also foster tumor growth.
Research examines the myths and science behind how the amino acid tryptophan, associated with turkey, affects mood.
Breast milk may help train the circadian clock in young babies. The hormonal composition of breast milk changes throughout the day, with cortisol levels being higher in the morning and melatonin levels being higher at night.
