MRC1+ macrophages are dysfunctional in animal models of neuropathic pain. Stimulating the expression of the anti-inflammatory protein CD163 reduced signs of neuroinflammation in the spinal cords of mice with neuropathic pain.
M2 macrophages can produce various endogenous opioids, such as endorphins, enkephalin, and dynorphin, which activate opioid receptors at the site of inflammation.
Dopamine may play a role in activating immune cells to migrate in the early stages of infection.
Whole-body vibration (WBV) therapy may be a way in which inflammation associated with diabetes can be controlled. WBV alters the microbiome, increasing levels of a bacterium that creates short-chain fatty acids, which help the body to better use glucose.
Advanced imaging techniques visualize macrophages in brain tumors in mouse models of glioblastoma.
PTEN deficiency drives an increased expression of LOX. LOX attracts macrophages which protect gliobastoma brain cancer cells and provide growth factor support for the tumor, a new mouse study reveals.
Using mouse models, researchers have developed a comprehensive map of the brain's immune cells. The study found microglia in the choroid plexus showed a similar activation state as microglia that come into contact with Amyloid deposits.
A new study reports some people with schizophrenia have increased numbers of immune cells in their brains. Researchers say the immune cells may be producing inflammatory signals in those with the condition.
A new study sheds light on how the circadian clock controls inflammatory response. By understanding the link between inflammation and circadian rhythm, researchers believe it may be most effective to target specific conditions at certain times of the day. The findings may also explain why those who experience body clock disruptions are more susceptible to inflammatory conditions.
Studying what the LRRK2 gene does in macrophages infected with the bacterium that causes tuberculosis, researchers believe they may have identified a cause of Parkinson's disease.
Researchers report inflammation reactions can cause long term alterations to immune cells in the brain which can influence the progression of neurodegenerative disorders later in life.
Researchers have discovered a method to engraft immune cells in the brains of lab mice without the use of radiation.
