FeaturedGeneticsNeuroscience·April 22, 2022·4 min readNew Discoveries About the Origin of the Brain’s Immune SystemNew findings reveal phagocytes do not fully mature until after birth, contradicting previous assumptions that they mature during embryonic development.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·November 24, 2021·3 min readNew Link Between a Disrupted Body Clock and Inflammatory DiseasesStudy identifies a significant way in which a disrupted circadian clock drives inflammation in the body's immune cells.Read More
FeaturedNeurologyNeurosciencePain·March 4, 2021·4 min readA New Cell Type Implicated in Chronic Pain and InflammationMRC1+ macrophages are dysfunctional in animal models of neuropathic pain. Stimulating the expression of the anti-inflammatory protein CD163 reduced signs of neuroinflammation in the spinal cords of mice with neuropathic pain.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·March 16, 2020·2 min readA new strategy for the management of inflammatory painM2 macrophages can produce various endogenous opioids, such as endorphins, enkephalin, and dynorphin, which activate opioid receptors at the site of inflammation.Read More
FeaturedGeneticsNeuroscienceOpen Neuroscience Articles·February 4, 2020·5 min readDopamine signals may guide migration of immune cells to infection sitesDopamine may play a role in activating immune cells to migrate in the early stages of infection.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·August 18, 2019·7 min readWhole body vibration shakes up microbiome, reducing inflammation in diabetesWhole-body vibration (WBV) therapy may be a way in which inflammation associated with diabetes can be controlled. WBV alters the microbiome, increasing levels of a bacterium that creates short-chain fatty acids, which help the body to better use glucose.Read More
Brain CancerFeaturedNeurologyNeuroscience·June 25, 2019·4 min readScientists track brain tumor turncoats with advanced imagingAdvanced imaging techniques visualize macrophages in brain tumors in mouse models of glioblastoma.Read More
Brain CancerFeaturedGeneticsNeurologyNeuroscience·June 10, 2019·5 min readStudy finds macrophages’ pathway to nurture PTEN-deficient glioblastoma: Mouse studyPTEN deficiency drives an increased expression of LOX. LOX attracts macrophages which protect gliobastoma brain cancer cells and provide growth factor support for the tumor, a new mouse study reveals.Read More
FeaturedGeneticsNeurologyNeuroscience·May 6, 2019·3 min readDetailed brain map uncovers hidden immune cells that may be involved in neurodegenerative disordersUsing mouse models, researchers have developed a comprehensive map of the brain's immune cells. The study found microglia in the choroid plexus showed a similar activation state as microglia that come into contact with Amyloid deposits.Read More
FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology·September 14, 2018·4 min readMore Immune Cells in Brains of Those with SchizophreniaA new study reports some people with schizophrenia have increased numbers of immune cells in their brains. Researchers say the immune cells may be producing inflammatory signals in those with the condition.Read More
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles·August 21, 2018·4 min readHow the Body Clock Controls InflammationA new study sheds light on how the circadian clock controls inflammatory response. By understanding the link between inflammation and circadian rhythm, researchers believe it may be most effective to target specific conditions at certain times of the day. The findings may also explain why those who experience body clock disruptions are more susceptible to inflammatory conditions.Read More
FeaturedGeneticsNeurologyOpen Neuroscience Articles·May 22, 2018·4 min readLink Between Tuberculosis and Parkinson’s Disease DiscoveredStudying what the LRRK2 gene does in macrophages infected with the bacterium that causes tuberculosis, researchers believe they may have identified a cause of Parkinson's disease.Read More
