The formation of plaques can cause the accumulation of spheroid-shaped swellings along axons near the amyloid plaque deposits. The swellings are caused by lysosomes, which digest cellular waste. As the swelling enlarges, it can block the transmission of signals from one area of the brain to another.
A new mouse study reveals a breakdown in the process that clears brain cells of waste products precedes the buildup of amyloid plaques associated with Alzheimer's disease.
Clioquinol, an anti-parasitic medication, overcomes the effect of mutations in the LRRK2 gene associated with Parkinson's disease by restoring the acidity of lysosomes and clearing out protein aggregates.
A new study reports antioxidant intervention during early stages of Parkinson's disease may help slow its progression.
A new tool allows researchers to observe granulins inside cells.
Researchers discover lysosomes can travel to dendrites and also be recruited by dendritic spines.
Summary: A new study reports researchers have identified a substance that can help to induce the reversal of aging. Source:...
Researchers have demonstrated the role of lysosomal vesicles in transporting α-synuclein aggregates.
A new study reports bone marrow transplants can significantly delay the onset of motor deficits in mouse models of MLIV.
Researchers report the chronic use of drugs to treat heartburn and GERDS can increase the risk of cardiovascular disease, vascular dementia and renal failure.
A new study reports cocaine induces autophagy in microglia and astrocytes. However, an experimental compound could counteract the process.
According to a new study, when two debris clearing proteins don't work together as they should, Parkinson's disease can occur.