Afimetoran, a newly developed pill to treat lupus, not only prevents lupus-like symptoms in mice, it also reverses signs of organ damage caused by the disease and prevents death. The medication is now undergoing phase 2 clinical trials to assess its effectiveness in lupus patients.
Researchers have developed small molecules that inhibit one of the main enzymes implicated in autoimmune response. The research could lead to potential new medications for a range of autoimmune diseases.
Researchers report they have found no increased risk of autoimmune diseases in girls who received the HPV4 vaccine. The study adds to a growing body of evidence for the safety of the vaccine.
Researchers have identified a protein they believe may cause the adverse reaction in the immune system of those suffering from Lupus. Reduced production of the Blimp-1 protein increased CTSS in females with Lupus, but not in males, the Nature Immunology study reports.
A study in Nature Immunology reports on the mechanism that helps to prevent autoimmune diseases from developing following infection. Researchers report a population of immune cells develop during late stages of the immune response to influenza infection.
A new study reveals why women are more likely to develop autoimmune conditions like lupus and Sjögren's syndrome, and men are more likely to develop schizophrenia. Researchers implicated the C4 gene in sex-based risk factors for autoimmune and psychiatric disorders.
Researchers have identified specific cellular events that appear key to the debilitating autoimmune disease, lupus. The findings suggest that blocking this pathway in lupus-triggering cells could be a potent weapon against the disease.
Skin cells may hold the key to explaining why women are more prone to developing autoimmune diseases, such as lupus than men. Researchers found women have more VGLL3 in their skin cells than men. VGLL3 pushes the immune system into overdrive, resulting in the 'self-attacking' autoimmune response, the mouse study revealed. Findings strongly implicate VGLL3 as a pivotal catalyst in sex-based autoimmunity.
People with the APOE4 genetic risk factor for Alzheimer's disease also have lower levels of the CRP inflammatory molecules in their spinal fluid. Researchers speculate these inflammatory molecules may be accumulating in the brain and causing damage, rather than floating freely in cerebrospinal fluid.