A new neuro-optics technique can manipulate memory consolidation in mouse models by hindering long-term potentiation. Researchers say eliminating local LTP in the hippocampus erased memories. The method could be used to isolate memory formation at the cellular level.
A pairing of presynaptic and postsynaptic activity in a population of hippocampal neurons can reduce the required number of synaptic plasticity evoking events. When spikes occur within ten milliseconds of each other, synapses strengthen for up to four hours.
Researchers report estrogen may play a significant role in synaptic plasticity and memory formation. The study reports mice whose neurons did not produce estrogen have impairments in spatial reference memories, recognition and contextual fear memories. Restoring estrogen levels assisted in reversing the memory impairments, the study revealed.
Researchers have identified a novel role the RGS14 protein plays in limiting synaptic plasticity.
Researchers report running can help mitigate the impact chronic stress has on the hippocampus.