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long-term potentiation

·June 7, 2024·5 min read

Brain’s Oxygen Deprivation Mechanism Hinders Memory Formation

Oxygen deprivation in the brain triggers a feedback loop involving glutamate and nitric oxide, causing anoxia induced long-term potentiation (aLTP). This process disrupts regular memory-enhancing mechanisms, potentially explaining memory loss post-stroke. The study offers insights into treating memory problems in stroke patients.

Electrophysiology Featured Neuroscience

·August 30, 2023·3 min read

LTP Theory of Learning and Memory Challenged

Researchers overturned three decades of scientific consensus about the role of LTP (Long-Term Potentiation) in memory and learning. The team discovered that it's not the enzymatic actions of CaMKII that are needed for LTP, but its structural functions.

Featured Neuroscience

·November 13, 2021·3 min read

A New Neural-Optic System Can Manipulate Memories

A new neuro-optics technique can manipulate memory consolidation in mouse models by hindering long-term potentiation. Researchers say eliminating local LTP in the hippocampus erased memories. The method could be used to isolate memory formation at the cellular level.

This shows an eraser removing a drawing of a brain

Featured Neurology Neuroscience Open Neuroscience Articles

·March 3, 2020·6 min read

Visceral fat delivers signal to the brain that hurts cognition

Visceral fat impairs memory via proinflammatory interleukin-1 beta mediated microglia activation in the hippocampus.

A detailed drawing of the hippocampal formation is shown.

Electrophysiology Featured Neuroscience

·March 27, 2019·6 min read

Quick thinking? It’s all down to timing

A pairing of presynaptic and postsynaptic activity in a population of hippocampal neurons can reduce the required number of synaptic plasticity evoking events. When spikes occur within ten milliseconds of each other, synapses strengthen for up to four hours.

Featured Neuroscience

·February 25, 2019·7 min read

Estrogen Made by Neurons Important to Memory Making

Researchers report estrogen may play a significant role in synaptic plasticity and memory formation. The study reports mice whose neurons did not produce estrogen have impairments in spatial reference memories, recognition and contextual fear memories. Restoring estrogen levels assisted in reversing the memory impairments, the study revealed.

Featured Neuroscience

·January 2, 2019·5 min read

How Does the Brain Learn by Talking to Itself?

A new study reveals the role synaptic feedback systems play in shaping learning processes. The findings could help develop more efficient artificial intelligence techniques.