leptin

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leptin

·August 25, 2018·5 min read

Destructive Mechanism That Blocks the Brain from Knowing When to Stop Eating Identified

Researchers report mice fed a high fat diet produce an enzyme called MMP-2, which results in leptin being blocked from binding to its receptors. This, they report, prevents neurons from signaling that the stomach is full. The study suggests blocking MMP-2 may help people with obesity to lose weight.

Featured Neuroscience

·October 18, 2018·4 min read

Weight Loss Success Linked with Active Self Control Regions of Brain

A new neuroimaging study found those who achieved greater success at losing weight showed increased activation in regions of the lateral prefrontal cortex, an area of the brain associated with self control.

Featured Genetics Neuroscience

·November 19, 2018·3 min read

Is the Gut or Brain More Important in Regulating Appetite and Metabolism?

Researchers debate the roles of the gut and brain hormones play in regulating appetite and metabolism.

Featured Neuroscience

·December 20, 2018·5 min read

Gut-Brain Connection Signals Behavioral Alterations While Eating: Worm Study

Researchers have identified neurons in the guts of C. elegans that detect when bacteria are ingested and release a neurotransmitter that signals the brain to halt locomotion.

This shows a weighing scale, a tape measure and an apple

Featured Neuroscience Open Neuroscience Articles

·May 2, 2019·3 min read

New brain mechanisms regulating body weight identified: Rodent study

Interleukin-6 interacts with leptin in the lateral parabrachial nucleus to reduce food intake. Reducing IL-6 in the IPBL increases weight gain and could help explain why some are more prone to overeating and obesity.

This shows a pregnant woman making a heart shape with her hands over her belly

Featured Neuroscience

·May 25, 2019·2 min read

Don’t overdo omega-6 fat consumption during pregnancy

Consuming too much omega 6 during pregnancy has been linked to an increased risk of neurodevelopmental issues in babies and pregnancy complications. In mice who had higher levels of linoleic acid in their diets, researchers noted altered concentrations of inflammatory proteins and a decrease in hormones that regulate fetal growth and development. Researchers stress the effects of a high linoleic acid concentration in diet are the same for both animal models and humans.

Featured Neuroscience

·July 22, 2020·5 min read

How Neurons Reshape Inside Body Fat to Boost Its Calorie-Burning Capacity

Normally bushy networks of neural fibers within fat tissue shrink in the absence of leptin, but grow back when the hormone is administered in drug form. The alterations influence the ability to burn energy stored in fat in mouse models.

Featured Neuroscience Open Neuroscience Articles

·August 12, 2020·3 min read

Exercise Makes Female Rats Hungrier and Sustains Weight Gain

Study in rats reveals sex differences may play a key role in the effectiveness of exercise as an appetite regulator. Exercising female rats ate more than those who did not partake in physical activity. The same effect was not seen in males.

Featured Neuroscience Open Neuroscience Articles

·April 6, 2021·4 min read

Leptin Puts the Brakes on Eating via Novel Neurocircuit

Researchers have identified novel neurocircuitry between midbrain structures which are modulated by leptin to control eating behaviors in mice.

Featured Neuroscience

·October 24, 2021·2 min read

How the Brain and Fat Tissue Communicate

A new study aims to generate a model of how the brain and body fat communication system controls the production and release of leptin. The study aims to discover how metabolism is regulated under different environmental challenges.

Featured Neuroscience Psychology

·December 12, 2022·5 min read

A Possible Neural Link Between Early Life Trauma and Binge-Eating Disorder Discovered

8 in 10 sufferers of binge eating disorders experienced trauma during childhood. Researchers discovered leptin is less effective in the lateral hypothalamus of those who suffered childhood trauma.

This is a graphical abstract from the study

Featured Neuroscience

·February 23, 2023·5 min read

Leptin Helps Hungry Mice Choose Sex Over Food

When their brains are stimulated with leptin, an appetite-suppressing hormone, hungry mice prioritize mating and interacting with mice of the opposite gender over eating.

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