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ketamine

·December 30, 2022·4 min read

Ketamine Found to Increase Brain Noise

By inhibiting NMDA receptors, ketamine increases noise to gamma frequencies in one layer of the thalamic nucleus and one lay of the somatosensory cortex. Findings suggest psychosis may be triggered by an increase in background noise impairing thalamocortical neurons which may be caused by a malfunction in NMDA receptors affecting the balance of inhibition and excitation in the brain.

Featured Genetics Neuroscience Open Neuroscience Articles

·March 11, 2020·2 min read

JNK protein triggers neurons to withdraw their synapses when stressed

Using optogenetics to inhibit the JNK protein prevented synapses from shrinking in response to stress.

Featured Neuroscience Open Neuroscience Articles Psychology

·May 21, 2019·5 min read

Study supports effectiveness of new fast-acting antidepressant, esketamine nasal spray

Esketamine combined with antidepressants acts rapidly to help alleviate symptoms in those with treatment-resistant depression.

Featured Neuroscience Psychology

·January 31, 2022·5 min read

Perception Study May Explain Promising Depression Therapy

Study demonstrates the importance of a specific type of connection between neurons and may also explain how ketamine shows promise in treating depression.

Image shows the chemical structure of AMPA.

Featured Neuroscience Videos Psychology

·May 4, 2016·6 min read

Ketamine Lifts Depression via a Byproduct of Its Metabolism

A metabolite created as the body breaks down ketamine could hold the key to understanding its antidepressant action, a new study reports.

Featured Neuroscience Open Neuroscience Articles

·July 6, 2021·4 min read

Rejuvenating Mouse Brains With Ketamine or Flickering Light

Ketamine and exposure to 60-hertz flickering light show promise as a potentially new, non-invasive therapy to help rejuvenate the aging brain.

Featured Neuroscience Psychology

·September 29, 2020·5 min read

Computer Model Explains Altered Decision Making in Schizophrenia

Summary: An artificial neural network has identified a potential mechanism for the impaired decision-making often seen in schizophrenia patients, which involves the reduced activity of NMDA receptors.

Image shows four subunits of NMDA receptor proteins.

Electrophysiology Featured Neuroscience

·October 9, 2017·6 min read

Nerve Cells’ Gatekeepers Take Many Forms

Rice University researchers detail the dynamics of how receptors alter their shapes to control sensitivity of the gate to chemical signals.

Featured Neuroscience Psychology

·October 19, 2023·6 min read

Does Drug Effect or Power of Belief Explain Ketamine’s Antidepressant Effect?

Researchers conducted a unique study to uncover the efficacy of ketamine in treating depression, bypassing its unmistakable psychedelic effects by administering it during surgery. Surprisingly, both the ketamine and placebo groups showed substantial improvement in depression symptoms.

Featured Neuroscience Psychology

·March 30, 2026·8 min read

Blocking NOX-1 Extends Ketamine’s Effectiveness for Depression

Researchers have identified the NOX-1 enzyme as the reason ketamine's antidepressant effects are short-lived. By blocking NOX-1, they extended the drug's benefits from days to weeks.

Featured Psychology

·May 10, 2016·6 min read

Intravenous Ketamine May Rapidly Reduce Suicidal Thinking in Depressed Patients: Small Study

Repeat intravenous treatment with low doses of the anesthetic drug ketamine quickly reduced suicidal thoughts in a small group of patients with treatment-resistant depression, a new study reports.

Featured Neuroscience Psychology

·June 20, 2025·6 min read

Ketamine Plus Therapy Offers Lasting Relief for Severe Depression

A first-of-its-kind clinical trial shows that ketamine treatment for severe, treatment-resistant depression is significantly more effective when paired with psychotherapy and supportive environments. Patients who underwent this combined treatment reported a 30% drop in depression symptoms, with reduced anxiety and suicidal thoughts lasting at least eight weeks.

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ketamine

Ketamine Found to Increase Brain Noise

JNK protein triggers neurons to withdraw their synapses when stressed

Study supports effectiveness of new fast-acting antidepressant, esketamine nasal spray

Perception Study May Explain Promising Depression Therapy

Ketamine Lifts Depression via a Byproduct of Its Metabolism

Rejuvenating Mouse Brains With Ketamine or Flickering Light

Computer Model Explains Altered Decision Making in Schizophrenia

Nerve Cells’ Gatekeepers Take Many Forms

Does Drug Effect or Power of Belief Explain Ketamine’s Antidepressant Effect?

Blocking NOX-1 Extends Ketamine’s Effectiveness for Depression

Intravenous Ketamine May Rapidly Reduce Suicidal Thinking in Depressed Patients: Small Study

Ketamine Plus Therapy Offers Lasting Relief for Severe Depression

Key Brain Circuit Linked to Teen Anxiety Identified

Early Blindness Tunes Pitch Perception

LSD Microdosing Enhances Sustained Attention in Women

Cannabis Destroys Sleep Quality

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