FeaturedNeurosciencePsychology·March 30, 2026·8 min readBlocking NOX-1 Extends Ketamine’s Effectiveness for DepressionResearchers have identified the NOX-1 enzyme as the reason ketamine's antidepressant effects are short-lived. By blocking NOX-1, they extended the drug's benefits from days to weeks.Read More
FeaturedNeuroscienceNeuroscience VideosPsychology·November 18, 2019·4 min readSide effects mild and brief with single antidepressant dose of intravenous ketamineThe side effects of administering ketamine to treat major depressive disorder are mild and persist for no longer than four hours, researchers report. Most of the side effects peaked within an hour of treatment, and many patients reported the effects as being significantly reduced two hours post ketamine administration.Read More
FeaturedPsychology·December 21, 2015·3 min readBrain Circuits Involved in Ketamine’s Antidepressant Effect IdentifiedNew understanding about ketamine's antidepressant effect could lead to the development of new, safer and quicker ways to treat depression.Read More
FeaturedPsychology·May 10, 2016·6 min readIntravenous Ketamine May Rapidly Reduce Suicidal Thinking in Depressed Patients: Small StudyRepeat intravenous treatment with low doses of the anesthetic drug ketamine quickly reduced suicidal thoughts in a small group of patients with treatment-resistant depression, a new study reports.Read More
FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology·June 1, 2020·4 min readHow ketamine combats depressionKetamine increases the number of serotonin 1B receptors. Ketamine binds to serotonin 1B receptors, reducing the release of serotonin and increasing the release of dopamine.Read More
ElectrophysiologyFeaturedNeuroscience·October 9, 2017·6 min readNerve Cells’ Gatekeepers Take Many FormsRice University researchers detail the dynamics of how receptors alter their shapes to control sensitivity of the gate to chemical signals.Read More
FeaturedNeurosciencePsychology·September 29, 2020·5 min readComputer Model Explains Altered Decision Making in Schizophrenia Summary: An artificial neural network has identified a potential mechanism for the impaired decision-making often seen in schizophrenia patients, which involves the reduced activity of NMDA receptors.Read More
FeaturedNeurosciencePsychology·May 16, 2019·5 min readKetamine: The illicit party psychedelic that promises to heal depressionKetamine, an anesthetics which has been commonly used as an illicit party drug, is helping people overcome depression. The drug works rapidly and provides lasting relief from depressive symptoms for weeks after exposure. Researchers are examining how ketamine works in the brain to help positively influence behavior in those with mood disorders.Read More
FeaturedOpen Neuroscience ArticlesPsychology·September 29, 2016·4 min readAlcohol Shown to Act in Same Way as Rapid AntidepressantsResearchers report alcohol produces the same neural and molecular changes as drugs that have proven to be rapidly effective antidepressants.Read More
FeaturedNeurosciencePsychology·February 18, 2021·4 min readNew Information on the Effects of AntidepressantsSSRI's, ketamine, and tricyclic antidepressants all bind with TrkB. The findings challenge the roles serotonin and glutamate receptors play in the effects of antidepressant medications.Read More
FeaturedNeurosciencePsychology·December 16, 2020·4 min readHow Does Ketamine Combat Depression?4E-BPs proteins are key to unlocking ketamine's antidepressant effects. When 4E-BPs are absent in neurons, ketamine can not produce its antidepressant effect.Read More
FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology·December 4, 2018·6 min readNew Insights Into Loss of Pleasure in DepressionA new study reveals a brain region that contributes to anhedonia, the loss of pleasure, in those with depression. The study also shows how ketamine acts on this brain region, explaining why the drug appears to be so effective at treating anhedonia.Read More
