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Karolinska Institute

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Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·November 3, 2022·3 min read

Inflammation May Amplify Effect of Genetic Risk Variants for Schizophrenia

Pro-inflammatory cytokines IL-1 beta and IL-6 stimulate the expression of the schizophrenia-related C4A gene. Patients with high C4A expression displayed increased levels of IL-1 beta in cerebral spinal fluid samples. C4A levels were also correlated with markers of synaptic density. Findings reveal inflammation enhances the genetic risk variant for schizophrenia.

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Featured Neuroscience Psychology

·May 14, 2022·6 min read

Six Lithium Dose Predictors for Patients With Bipolar Disorder

Researchers have identified six predictors that may help determine the correct amount of lithium to treat a patient with bipolar disorder.

Featured Neuroscience Psychology

·January 12, 2024·6 min read

Perinatal Depression: Decades of Elevated Mortality Risk

A new study highlights the long-term mortality risks associated with perinatal depression. Analyzing data from over 86,500 women, the research found that those experiencing depression during or shortly after pregnancy are at a higher risk of death from natural and unnatural causes for up to 18 years post-diagnosis.

Brain Cancer Featured Genetics Neuroscience

·January 21, 2023·2 min read

Protein Movement Reveals Brain Tumor’s Weak Spot

In glioblastoma brain cancer, EGFR (HER1) genetic mutations lead to a movement of a large part of the extracellular region of the protein. This activates the intracellular area in a particular way that drives glioblastoma tumor development.

Featured Neuroscience Open Neuroscience Articles

·April 2, 2020·4 min read

Trial drug may block early stages of COVID-19, human cell study shows

hrsACE2, a genetically modified protein already being tested to prevent lung disease, reduces the viral growth of SARS-CoV-2 by a factor of 1,000 to 5,000 in human cell cultures. Researchers believe the enzyme copy lures the virus to attach itself to the copy, rather than human lung cells. The findings suggest hrsACE2 could significantly block the early stages of SARS-CoV-2 infections and prevent COVID-19 from becoming severe.

Featured Genetics Psychology

·May 21, 2018·4 min read

Cell Types Underlying Schizophrenia Identified

Researchers have identified different neuron types and provided a new list of genes associated with schizophrenia. The findings could pave the way for developing new targeted therapies to treat the condition.

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Featured Neuroscience Open Neuroscience Articles

·September 13, 2019·4 min read

Discovery concerning the nervous system overturns a previous theory

Rather than having an equal chance of survival, cell death appears to be controlled by a mechanism that filters our the less fit cells.

Featured Neurology Neuroscience

·April 16, 2023·5 min read

Sugar Molecule in Blood Can Predict Alzheimer’s Disease

Blood levels of glycans, structures made up of sugar molecules that are associated with tau levels in the brain, are altered in the early stages of Alzheimer's disease, researchers discovered.