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Karolinska Institute

Featured Genetics Neurology Neuroscience

·November 5, 2025·6 min read

3D Brain Map Reveals How Inflammation Reawakens Developmental Genes

Researchers have developed the most detailed molecular map yet of how the brain develops and reacts to inflammation, revealing that disease processes can “reawaken” genes from early life. Using a new spatial tri-omics technique, the team tracked how gene activity, epigenetic changes, and protein production interact in specific brain regions.

Featured Genetics Neuroscience

·November 22, 2024·3 min read

3D RNA Imaging Revolutionizes Brain Research

Researchers have developed TRISCO, a cutting-edge microscopy method that enables 3D RNA analysis in whole, intact mouse brains without slicing them into sections. TRISCO reveals RNA molecules’ spatial distribution, providing unprecedented insights into the brain’s complex structure and function.

Featured Neuroscience

·November 27, 2022·3 min read

A Brain Circuit Underpinning Locomotor Speed Control

A neural circuit that decodes the start, duration and sudden change of speed of locomotion has been identified.

Featured Neuroscience Open Neuroscience Articles

·December 27, 2019·3 min read

A molecular map of the brain’s decision-making area

Using RNA sequencing, researchers have created a spatiomolecular map of the striatum, an area of the brain implicated in decision making and addiction.

Featured Neurology Neuroscience

·March 28, 2023·4 min read

A Novel Biomarker for Early Diagnosis of Alzheimer’s Disease

Astrocytic α7-subunit of the nicotinic acetylcholine receptors (α7nAChRs) have been implicated as a novel biomarker for the diagnosis of early Alzheimer's disease.

Featured Neuroscience Psychology

·April 8, 2019·2 min read

A sleep-deprived brain interprets impressions negatively

Sleep loss leads to negativity bias, negative mood and impaired emotional regulation.

Featured Neurology Neuroscience

·October 18, 2022·5 min read

Absence of Biomarker Profiles Typical of Alzheimer’s Disease

Findings highlight the need to continue developing new disease-modifying treatments with different mechanisms of action for patients with Alzheimer's disease.

This shows Vyvanse (Lisdexamfetamine) 70mg capsules

Featured Neuroscience Psychology

·November 17, 2022·5 min read

ADHD Medication for Amphetamine Addiction Linked to Reduced Risk of Hospitalization and Death

Lisdexamfetamine (Vyvanse), a medication commonly used to treat ADHD, lowers the risk of hospitalization and death for those with amphetamine use disorder.

This shows a woman sitting on a chair, surrounded by swirly lines and question marks

Featured Neurology Neuroscience Open Neuroscience Articles Psychology

·July 10, 2021·5 min read

Adult ADHD Is Linked to Numerous Physical Conditions

A new study reveals adults with ADHD have an increased risk of developing nervous system, respiratory, musculoskeletal, and metabolic diseases. ADHD was also associated with a slightly increased risk of Parkinson's disease, dementia, and cardiovascular disease.

Featured Neurology Neuroscience

·May 17, 2019·4 min read

Adult-onset inflammatory bowel disease linked to higher mortality

Diagnosis of inflammatory bowel diseases like Crohn's disease and ulcerative colitis during adulthood has been linked to a 50% higher mortality rate and shorter life expectancy in those over 50. The increased risk of death remained after the introduction of therapies aimed at treating the conditions but decreased over time.

Featured Neuroscience

·May 25, 2018·3 min read

Aggression Neurons Identified

Researchers implicated a group of neurons in the premammillary nucleus of the hypothalamus with aggressive behaviors. Using optogenetics to stimulate and inhibit these neurons, researchers were able to control aggression in mice.

Featured Neurology Neuroscience

·December 20, 2024·5 min read

AI Estimates Brain Age, Links Lifestyle to Cognitive Health

Researchers used AI to analyze brain images from 70-year-olds, estimating their biological brain age and uncovering connections to lifestyle and health factors. Diabetes, inflammation, and high glucose levels were linked to older-looking brains, while regular exercise and healthy habits were associated with younger-looking brains.

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Karolinska Institute

3D Brain Map Reveals How Inflammation Reawakens Developmental Genes

3D RNA Imaging Revolutionizes Brain Research

A Brain Circuit Underpinning Locomotor Speed Control

A molecular map of the brain’s decision-making area

A Novel Biomarker for Early Diagnosis of Alzheimer’s Disease

A sleep-deprived brain interprets impressions negatively

Absence of Biomarker Profiles Typical of Alzheimer’s Disease

ADHD Medication for Amphetamine Addiction Linked to Reduced Risk of Hospitalization and Death

Adult ADHD Is Linked to Numerous Physical Conditions

Adult-onset inflammatory bowel disease linked to higher mortality

Aggression Neurons Identified

AI Estimates Brain Age, Links Lifestyle to Cognitive Health

PCOS/PMOS Increases Alzheimer’s Risk

Alcohol Tricks Brain Cells Into Destroying Themselves

Daytime Napping Linked to Higher Risk of Dementia

Prenatal Stress Alters the Placenta to Shape Fetal Brain Development

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