Researchers identified 20 drug candidates that reduce C4 immune protein secretion from astrocytes. The discovery could pave the way to treating schizophrenia and other disorders associated with C4 dysregulation in astrocytes.
Neurons derived from stem cells of combat veterans with PTSD react differently to stress hormones than those derived from veterans without PTSD. The findings shed new light on how genetics can cause some to develop PTSD following a traumatic event.
Researchers successfully turned skin cells from Parkinson's patients into dopaminergic neurons by introducing a combination of neural-inducing genes into the skin cells.
Researchers have designed a new method of converting non-neural cells into functioning neurons that are able to form synapses, dispense dopamine, and restore the function of neurons undermined by Parkinson's associated destruction of dopaminergic cells.
Atypical brain development begins at the very earliest stages of brain organization, at the level of individual neurons.
Human-on-a-chip technology could provide a more valuable clinical-based model for ALS.
Study finds allele-specific open chromatin variants are likely to be linked to several neuropsychiatric traits and illnesses, including schizophrenia and bipolar disorder.
Study points to a common gene expression profile, regardless of DNA mutations, applicable to any person on the autism spectrum. The dysregulation occurs in neural progenitor cells. While the genetic cause of ASD may be different between individuals, the behavior of the genes is similar in people with autism, and differ from those who are not on the autism spectrum.
10% of patients diagnosed with Parkinson's disease are between the ages of 21 and 50. For those with young-onset Parkinson's disease, researchers report the foundations for the disease may have been apparent before they were born. The study also points to a drug, currently approved to treat precancerous skin growths, that has the potential to reduce elevated levels of alpha-synuclein.
Using induced pluripotent stem cells derived from patients with neurodegenerative disorders, researcher recreated the blood-brain barrier inside Organ-Chips.
Researchers have developed a new technique to study the development of human neurons compared to the neurons of nonhuman primates. The findings shed new light on the evolution of the human brain.
Using CRISPR gene editing technology, researchers discover increased activity in neurons deficient in the CNTN5 or EHMT2 genes may cause ASD related characteristics in humans.
