New research discovers an early step in how the brain's inhibitory cells get excited. Erbin, a protein critical to brain development, is also crucial for the excitement of inhibitory cells.
Researchers discover how parvalbumin-expressing interneurons, which usually limits stem cell activity, can also encourage the survival of the stem cells' progeny.
A study suggests that spinal muscular atrophy (SMA), a genetic neuromuscular disease in infants and children, results primarily from motor circuit dysfunction, not motor neuron or muscle cell dysfunction, as is commonly thought. In a second study, the researchers identified the molecular pathway in SMA that leads to problems with motor function.
A new paper hypothesizes that a particular type of interneuron may influence responses in a context dependent manner.
A new study reveals selenium is essential for the postnatal development of a specific type of interneuron.
A low dose of the sedative clonazepam alleviated autistic-like behavior in mice with a mutation that causes Dravet syndrome in humans.
Gene expression patterns in four regions of the prefrontal cortex are distinctly different in those who have been diagnosed with PTSD compared to those who have not. Major differences were seen in interneurons, which inhibit the immune system and microglia in the central nervous system. Findings shed light on why women are more likely to experience PTSD and compound a link between post-traumatic stress and a dampening of the immune system.