In rheumatoid arthritis, inflammation in one joint is transmitted to other joints via the sensory neuron connections in the spinal cord, leading to inflammation in the other joints. Inflammation in one joint led to an increase in ATP in other joints, which triggered an increase of a signaling molecule that resulted in inflammation. Blocking the pathway reduced the spread of inflammation.
Gene expression patterns in four regions of the prefrontal cortex are distinctly different in those who have been diagnosed with PTSD compared to those who have not. Major differences were seen in interneurons, which inhibit the immune system and microglia in the central nervous system. Findings shed light on why women are more likely to experience PTSD and compound a link between post-traumatic stress and a dampening of the immune system.
A new study implicated interneurons and pyramidal cells in the ability of a seizure to spread through the brain.
A new study reveals how interneurons emerge and diversify in the brain.
A new study reveals selenium is essential for the postnatal development of a specific type of interneuron.
Coupling training to reduce fear and transplanting embryonic interneurons into the amygdala of mice, researchers were able to reduce fear response, a new study reports.
Researchers have developed a new method that combines genetic markers and virus particles to target GABA cell types with a high degree of specificity.
A new study of mice finds early exposure to stress can make specific brain regions mature faster.