Adora2a mediating signaling in vascular endothelial cells disrupts the blood-brain barrier in obesity. This, researchers report, could be an underlying mechanism for synaptic plasticity and cognitive deficits in those with insulin resistance and obesity.
The insulin-like growth factor II gene plays a critical role in adult stem cell maintenance of both the intestine and the brain. Findings suggest IGF-2 is essential for multiple stem cell types, including those implicated in cognitive function and renewing the lining of the small intestine.
Whole-body vibration (WBV) therapy may be a way in which inflammation associated with diabetes can be controlled. WBV alters the microbiome, increasing levels of a bacterium that creates short-chain fatty acids, which help the body to better use glucose.