Surfen, a compound molecule used for drug delivery of insulin could block tumor growth for patients with glioblastoma brain cancer.
Maternal exposure to a high-fat diet during pregnancy and lactation can have a lasting, detrimental effect on the cognitive ability and behaviors of their offspring.
Islets of Langerhans in overnourished infant mice showed epigenetic profiles resembling those of much older mice.
Ginkgo Biloba, a popular herbal supplement, may help in the treatment of Type 2 diabetes. The supplement had a promising effect on beta cells of Langerhans in rat models of the disease. Additionally, Ginkgo Biloba reduced oxidative stress associated with type 2 diabetes.
Whole-body vibration (WBV) therapy may be a way in which inflammation associated with diabetes can be controlled. WBV alters the microbiome, increasing levels of a bacterium that creates short-chain fatty acids, which help the body to better use glucose.
Children with type 1 diabetes have slower growth of total cortical and subcortical gray and white matter compared to their peers without diabetes.
A new study in fruit fly models reveals STRIPAK components act as a switch to turn off quiescence and turn on the reactivation of neural stem cells.
A variant of the CHC22 gene evolved to help people adapt to the modern, higher sugar diet. However, many people still retain the older version of the genetic variant, which does not allow for correct metabolism of modern diets and may be linked to an increased risk of developing diabetes.
Study finds a pathogenic relationship between insulin resistance and fibromyalgia. Treating fibromyalgia with metformin, a drug that combats insulin resistance, resulted in a dramatic reduction of pain levels for patients.
A combination of chronic stress and high-calorie diets raised insulin levels tenfold in the amygdala of mice. Prolonged high levels of insulin in the central amygdala resulted in neurons becoming desensitized to insulin. The desensitized neurons boosted NPY levels, which promoted eating and reduced the normal homeostasis response to burn calories. The findings may shed light on why some indulge in high-calorie foods when stressed, and why this may lead to obesity.
Adora2a mediating signaling in vascular endothelial cells disrupts the blood-brain barrier in obesity. This, researchers report, could be an underlying mechanism for synaptic plasticity and cognitive deficits in those with insulin resistance and obesity.
The insulin-like growth factor II gene plays a critical role in adult stem cell maintenance of both the intestine and the brain. Findings suggest IGF-2 is essential for multiple stem cell types, including those implicated in cognitive function and renewing the lining of the small intestine.
