A new way to study the role of a critical neurotransmitter in disorders such as epilepsy, anxiety, insomnia, depression, schizophrenia, and alcohol addiction has been developed. This model synapse can precisely control a variety of receptors for the neurotransmitter called GABA, which is important in brain chemistry.
Neuroscientists report that two major classes of brain cells repress neural activity in specific mathematical ways: One type subtracts from overall activation, while the other divides it.
Frequently, as many as one thousand signals rain down on a single neuron simultaneously. To ensure that precise signals are delivered, the brain possesses a sophisticated inhibitory system. Scientists have now illuminated how this system works.
Scientists have observed the neurological mechanism behind temperature-dependent febrile seizures by genetically engineering fruit flies to harbor a mutation analogous to one that causes epileptic seizures in people. Their new study also highlights the first use of genetic engineering to swap a human genetic disease mutation into a directly analogous gene in a fly.
Researchers examine the how fear responses are learned, controlled, and memorized. They show that a particular class of neurons in a subdivision of the amygdala plays an active role in these processes.
A study shows another family of proteins linked to neurodevelopmental disorders regulates the function of neuroligins and neurexins in order to suppress the development of inhibitory synapses.
New research discovers an early step in how the brain's inhibitory cells get excited. Erbin, a protein critical to brain development, is also crucial for the excitement of inhibitory cells.
Finding may lead to new approaches to treating familial schizophrenia.
A new study uncovers 140 proteins that have never previously been mapped to inhibitory synapses.
Study identifies the role a specific protein plays in regulating the development of inhibitory synapses in the hippocampus in the context of anxiety-related behaviors.