Silencing pyramidal neurons in the infralimbic cortex made rats more likely to relapse than those that underwent withdrawal from cocaine. The findings support growing evidence that the infralimbic cortex plays a vital role in suppressing addictive behaviors.
Neurons in the infralimbic cortex control the link between food cues and behavioral actions, such as overeating or bad food choices. When these neurons are regulated, the rat models consumed fewer treats.
Study reveals how two neural circuits dictate the choice between social approach and avoidance. The network connecting the infralimbic cortex to the basolateral amygdala (BLA) impairs social behavior if there is a decrease in neural activity. Another network connecting the prelimbic cortex to the BLA similarly impairs social behavior if the neural activity is increased.