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IL-6

Featured Neurology Neuroscience Open Neuroscience Articles

·March 13, 2023·4 min read

Epilepsy Could Become Easier to Pinpoint With Blood Test

Higher levels of immune proteins are present in the blood both before and after an epileptic seizure. Researchers say the biomarkers can be identified via a simple blood test.

Featured Neuroscience Psychology

·December 16, 2022·5 min read

Inflammation May Explain Antidepressants’ Link to Preterm Birth

The common antidepressant Prozac (fluoxetine) provokes an inflammatory response in the amniotic sac. The findings may reveal the underlying factor of why women who take SSRI antidepressants are at higher risk of preterm birth.

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Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·November 3, 2022·3 min read

Inflammation May Amplify Effect of Genetic Risk Variants for Schizophrenia

Pro-inflammatory cytokines IL-1 beta and IL-6 stimulate the expression of the schizophrenia-related C4A gene. Patients with high C4A expression displayed increased levels of IL-1 beta in cerebral spinal fluid samples. C4A levels were also correlated with markers of synaptic density. Findings reveal inflammation enhances the genetic risk variant for schizophrenia.

Brain Cancer Featured Neurology Neuroscience

·November 26, 2021·4 min read

Drug Designed for Alzheimer’s Disease May Hold Promise for Treating Glioblastoma

A class of drugs called BACE1 inhibitors, originally designed to treat Alzheimer's disease, shows potential for the treatment of glioblastoma brain cancer.

Featured Neuroscience

·November 1, 2021·3 min read

Social Isolation Linked to Higher Markers of Inflammation in Older Adults

Blood samples taken from older adults who experienced social isolation had higher levels of interleukin-6 and C-reactive protein, two biomarkers of inflammation.

Featured Neurology Neuroscience

·August 20, 2021·3 min read

Physical Exercise Modulates Iron in Alzheimer’s Disease

Regular exercise modulates iron storage and trafficking in the brain and skeletal muscles, and physical activity reduces cortical hepcidin. The findings reveal how exercise can be beneficial for those with Alzheimer's disease.

Featured Neuroscience Open Neuroscience Articles

·June 4, 2020·3 min read

Proteins in the blood of COVID-19 patients could help predict how ill they will become

Researchers have identified 27 protein biomarkers that can predict whether a patient with COVID-19 is likely to develop severe coronavirus symptoms.

Featured Neuroscience Open Neuroscience Articles

·May 20, 2020·3 min read

COVID-19 cytokine storm: Possible mechanism for the deadly respiratory syndrome

SARS-CoV-2, the virus responsible for COVID-19, enters human cells by attaching to ACE2 and utilizing TMPRSS2. Drugs that block ACE2 or inhibit the enzyme could help treat the coronavirus, but only during early infection. As the infection progresses, SARS-CoV-2 becomes engulfed in human cells, reducing the number of ACE2 receptors on a cell and leading to an increase of angiotensin II in the blood. Angiotensin II triggers an inflammatory pathway, providing a positive feedback cycle, named IL-6 amplifier, resulting in excessive immune activation and the cytokine storm associated with severe COVID-19.

Featured Neuroscience Open Neuroscience Articles

·May 14, 2020·4 min read

Arthritis drug Anakinra may improve respiratory function in some patients with severe COVID-19

Anakinra, a clinically approved anti-inflammatory used to treat rheumatoid arthritis, improves respiratory function in patients with severe COVID-19 infection.

This shows someone holding a box of actemra

Featured Neurology Neuroscience

·May 3, 2020·2 min read

Arthritis Drug Presents Promise as Treatment for COVID-19 Pneumonia

UCSD has launched a Phase III clinical trial to assess whether tocilizumab (Actemra), a drug commonly prescribed for rheumatoid arthritis and other inflammatory disorders, has therapeutic value for those at risk of developing severe COVID-19 infection. The drug is a monoclonal antibody-based therapy that blocks receptors for interleukin-6, a cytokine that triggers inflammation as an early immune response to coronavirus. Blocking IL-6 could prevent the risk of the COVID-19 associated cytokine storm many with severe infection experience.

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Featured Neurology Neuroscience Psychology

·March 5, 2020·3 min read

Social isolation could cause physical inflammation

Socially isolated individuals may have an increased risk of physical inflammation in the body. Researchers found social isolation was associated with the presence of C-reactive protein and increased levels of glycoprotein fibrinogen. The link between social isolation and physical inflammation was more common in males.

This shows a weighing scale, a tape measure and an apple

Featured Neuroscience Open Neuroscience Articles

·May 2, 2019·3 min read

New brain mechanisms regulating body weight identified: Rodent study

Interleukin-6 interacts with leptin in the lateral parabrachial nucleus to reduce food intake. Reducing IL-6 in the IPBL increases weight gain and could help explain why some are more prone to overeating and obesity.

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IL-6

Epilepsy Could Become Easier to Pinpoint With Blood Test

Inflammation May Explain Antidepressants’ Link to Preterm Birth

Inflammation May Amplify Effect of Genetic Risk Variants for Schizophrenia

Drug Designed for Alzheimer’s Disease May Hold Promise for Treating Glioblastoma

Physical Exercise Modulates Iron in Alzheimer’s Disease

Proteins in the blood of COVID-19 patients could help predict how ill they will become

COVID-19 cytokine storm: Possible mechanism for the deadly respiratory syndrome

Arthritis drug Anakinra may improve respiratory function in some patients with severe COVID-19

Arthritis Drug Presents Promise as Treatment for COVID-19 Pneumonia

New brain mechanisms regulating body weight identified: Rodent study

Wasabi Compound Enhances Memory

Genes Associated with Earlier and Higher Reproduction Linked to Accelerated Aging

Novel Multiple Sclerosis Treatment Shows Promise

Brain’s Response to Crucial Language Hub Removal: New Insights

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