Exploring the relationship between emotion and pain in rheumatoid arthritis, researchers report emotions may function as a stressor, promoting inflammation and causing pain symptoms.
Anakinra, a clinically approved anti-inflammatory used to treat rheumatoid arthritis, improves respiratory function in patients with severe COVID-19 infection.
UCSD has launched a Phase III clinical trial to assess whether tocilizumab (Actemra), a drug commonly prescribed for rheumatoid arthritis and other inflammatory disorders, has therapeutic value for those at risk of developing severe COVID-19 infection. The drug is a monoclonal antibody-based therapy that blocks receptors for interleukin-6, a cytokine that triggers inflammation as an early immune response to coronavirus. Blocking IL-6 could prevent the risk of the COVID-19 associated cytokine storm many with severe infection experience.
For those who find it difficult to exercise, taking a hot bath can help improve inflammation and glucose levels, a new study reports.
SARS-CoV-2, the virus responsible for COVID-19, enters human cells by attaching to ACE2 and utilizing TMPRSS2. Drugs that block ACE2 or inhibit the enzyme could help treat the coronavirus, but only during early infection. As the infection progresses, SARS-CoV-2 becomes engulfed in human cells, reducing the number of ACE2 receptors on a cell and leading to an increase of angiotensin II in the blood. Angiotensin II triggers an inflammatory pathway, providing a positive feedback cycle, named IL-6 amplifier, resulting in excessive immune activation and the cytokine storm associated with severe COVID-19.
New findings could open the doors for the development of treatments for chronic pain.
Researchers have identified two compounds derived from grapes that might help to treat those with major depressive disorder.
Researchers report an exaggerated immune response can trigger chronic fatigue syndrome. The study reveals levels of Il-10 were higher in those who developed lasting fatigue, suggesting the immune system may have been primed to over respond.
A new study reveals immune system activation during pregnancy can have an impact on brain development in the offspring. Researchers report both short and long term brain function can be influenced by immune system activation during the third trimester.
A small study supports the mounting evidence that targeted immunotherapy can help improve cognitive ability in people with schizophrenia.