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·October 1, 2019·3 min read

A brain protein that could put the brakes on Alzheimer’s

Reducing the expression of the protein TOM1 in mouse models of Alzheimer's disease increased the pathology, exacerbated cognitive problems, and raised levels of inflammation in the brain. Restoring TOM1 reversed the effects. Findings suggest a new therapeutic target for treating dementia.

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·May 14, 2020·4 min read

Arthritis drug Anakinra may improve respiratory function in some patients with severe COVID-19

Anakinra, a clinically approved anti-inflammatory used to treat rheumatoid arthritis, improves respiratory function in patients with severe COVID-19 infection.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·August 21, 2018·4 min read

How the Body Clock Controls Inflammation

A new study sheds light on how the circadian clock controls inflammatory response. By understanding the link between inflammation and circadian rhythm, researchers believe it may be most effective to target specific conditions at certain times of the day. The findings may also explain why those who experience body clock disruptions are more susceptible to inflammatory conditions.

Image shows vesocles being released by astrocytes.

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·May 18, 2017·6 min read

How the Injured Brain Tells the Body It’s Hurt

Researchers uncover the mechanism that alerts immune cells to travel to the site of injury in the brain.

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·May 7, 2019·3 min read

Scientists pinpoint potential new target for regulating inflammation

SARM, an ancient immune protein previously implicated in apoptosis, is a key immune regulator in peripheral immune cells. The finding could help in the development of treatments for a range of diseases, including Alzheimer's, cancer and diabetes.

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·June 3, 2021·2 min read

Secondary Infections Inflame the Brain, Worsening Cognition in Alzheimer’s Disease

Secondary infections and novel inflammatory events, even ones that occur external to the brain, amplify the brain's immune response and detrimentally impact cognition in mouse models of Alzheimer's disease.