Autoreactive cytotoxic CD8 T cells have been detected in people with narcolepsy type one. The finding suggests levels of the T-cell reactivity, combined with specific gene expression, may spur on the development of NT1.
Researchers have identified two subpopulations of neurons in the BNST that connect to separate populations of neurons in the lateral hypothalamus which appear to drive two opposing emotional states; avoidance and reward seeking
Researchers at Johns Hopkins have identified specific neurons in the zona incerta that appear to help promote sleep. The discovery could help develop new treatments for insomnia and other sleep disorders.
A new study published in brain reveals that just one night of sleep disruption causes an increase in amyloid beta in the brains of healthy, middle aged people. A full week of sleep disturbances leads to a build up of Tau, another protein associated with Alzheimer's and other neurodegenerative diseases. The study sheds light on why poor sleep has previously been associated with the development of Alzheimer's and other dementias.
Histamine could be the cause of loss of hypocretin cells in narcolepsy sufferers, a new study suggests.