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Huntington’s disease

Featured Genetics Neurology Neuroscience

·December 12, 2022·4 min read

CRISPR Technology Improves Huntington’s Disease Symptoms in Models

Using CRISPR gene editing to directly target RNA, researchers eliminated toxic protein buildup associated with Huntington's disease while not disrupting other human genes.

Featured Genetics Neurology

·February 23, 2018·5 min read

Decoding the Structure of Huntintin

Researchers have decoded the 3D structure of the Huntingtin protein. The discovery may help develop new treatments for Huntington's disease.

Featured Genetics Neurology

·August 15, 2016·4 min read

Defect in Process That Controls Gene Expression May Contribute to Huntington’s Disease

Researchers reveal the role PRC2 plays in Huntington's disease and other neurodegenerative diseases.

Featured Neurology Neuroscience

·September 19, 2022·3 min read

Discovery of the Causes of Brain Dysfunction in Patients With Huntington’s Disease

Researchers discovered decreased function in a protein critical for synaptic function in those with Huntington's disease.

This image shows a scheme of the generation of induced pluripotent stem (iPS) cells.

Featured Genetics Neurology Open Neuroscience Articles

·September 5, 2014·2 min read

Disease in a Dish Approach Could Aid Huntington’s Disease Discovery

Researchers use iPSCs to create a disease in a dish model of Huntington's disease in transgenic nonhuman primates.

Featured Genetics

·September 13, 2016·5 min read

DNA Altering Technology Could Help Tackle Diseases

Researchers have developed a new protein that can alter DNA in living cells with much higher precision than current methods.

Featured Genetics Neurology

·December 12, 2017·2 min read

Drug Lowers Deadly Huntington’s Protein

UCL researchers report clinical trials of IONIS-HTTRx have shown success in reducing the huntinting protein in the nervous system of those with Huntington's disease. The drug is safe and well tolerated by human patients, the researchers note.

This is a graphic abstract from the study

Featured Genetics Neurology Neuroscience

·January 7, 2021·6 min read

Effects of Huntington’s Disease Mutation May Begin in Childhood

A new study adds to the growing body of evidence that the origin of Huntington's disease is rooted in childhood. Researchers say the HTT gene mutation affects both brain and body growth during development, and the increased susceptibility of brain cell death begins early in life.