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          Huntington’s disease

          Genetics
          ·September 18, 2012·1 min read

          New Findings on Protein Misfolding

          Researchers identified 21 proteins that specifically bind to a protein called ataxin-1. Twelve of these proteins enhance the misfolding of ataxin-1 and thus promote the formation of harmful protein aggregate structures, whereas nine of them prevent the misfolding.
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          FeaturedNeurology
          ·September 17, 2012·3 min read

          Toxic Protein Build-up in Blood Shines Light on Fatal Brain Disease

          A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells.
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          FeaturedGeneticsNeurology
          ·July 11, 2012·3 min read

          Two Proteins Offer a Clearer Way to Treat Huntington’s Disease

          HD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.
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          FeaturedGeneticsNeurology
          ·June 28, 2012·3 min read

          Human Model of Huntington’s Disease Created from Skin’s Stem Cells

          ‘HD in a dish’ will facilitate search for elusive treatment. An international consortium of Huntington’s disease experts, including several from...
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          FeaturedNeurologyNeuroscience Videos
          ·June 27, 2012·3 min read

          Nerve Pathway for Combating Axon Injury and Stress May Hold Benefits for Individuals With Neurodegenerative Disorders

          Researchers from the Huck Institutes’ Center for Cellular Dynamics, led by Center director Melissa Rolls, have found that a neuroprotective...
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          Brain CancerFeaturedGeneticsNeurologyNeuroscience
          ·June 20, 2012·3 min read

          Proposed Drug May Reverse Huntington’s Disease Symptoms

          Single treatment produces long-term improvement in animal models. With a single drug treatment, researchers at the Ludwig Institute for Cancer...
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          FeaturedGeneticsNeurology
          ·June 7, 2012·3 min read

          Researchers Identify Gene that Promotes Axon Destruction

          Findings could have broad therapeutic potential for many neurodegenerative diseases. Degeneration of the axon and synapse, the slender projection through...
          Read More
          Neurology
          ·April 3, 2012·3 min read

          Former Professional Baseball Pitcher Now Keeps His Strike Zone in Proteins

          Perhaps no other biochemist in the world has his own baseball card, but University of Massachusetts Amherst doctoral student Elih...
          Read More
          Neuroscience
          ·March 30, 2012·3 min read

          Biologists Identify a Key Enzyme Involved in Protecting Nerves From Degeneration

          A new animal model of nerve injury has brought to light a critical role of an enzyme called Nmnat in...
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          FeaturedNeurology
          ·March 15, 2012·3 min read

          Stem Cells Hint at Potential Treatment for Huntington’s Disease

          Huntington’s disease, the debilitating congenital neurological disorder that progressively robs patients of muscle coordination and cognitive ability, is a condition...
          Read More
          Neurology
          ·June 24, 2011·2 min read

          Lithium Profoundly Prevents Brain Damage Associated with Parkinson’s Disease

          Buck Institute research in mice moves into preclinical stage; working toward human trials Lithium profoundly prevents the aggregation of toxic...
          Read More
          FeaturedNeurologyNeuroscience
          ·May 18, 2011·3 min read

          Neutrons Provide First Sub-nanoscale Snapshots of Huntington’s Disease Protein

          Energy’s Oak Ridge National Laboratory and the University of Tennessee have for the first time successfully characterized the earliest structural...
          Read More
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          Blurry Beginnings Shape Brain’s Visual Pathways

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          Human Brains Keep Making Memory Neurons in Adulthood

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          Gene Therapy Restores Hearing in Those with Deafness

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          Forever Chemicals May Disrupt Brain Development

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