Certain reproductive events, such as early menstruation, early menopause, and hysterectomy were linked to an increased risk of a woman developing dementia later in life. Women who experienced pregnancy or who entered into menopause later were at a lower risk for dementia.
Hormone replacement therapy (HRT) use was associated with better cognition, memory, and larger brain volume in women who carry the Alzheimer's associated APOE4 genetic variant.
Despite previous claims, new research finds there is no link between menopausal women taking hormone replacement therapy (HRT) and an increased risk of developing dementia.
A new study reports mother rats who received hormone replacement therapy responded worse to memory and spatial learning tasks than those who had not given birth. Researchers suggest a woman's reproductive history could impact how the brain responds to hormones later in life.