Researchers reveal the role GLAST plays in establishing and maintaining neural wiring of Purkinje cells.
According to a PNAS study, the RNAs of tick borne encephalitis virus (TBEV) are transported from the cell body to dendrites. The viral RNAs then reproduce the viruses within the dendrites, disturbing neural activity.
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Whether a person is familiar to the animal or not, horses integrate human facial expressions and vocal tones to perceive human emotion, a new study reports.
Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain.
SARS-CoV-2, the virus responsible for COVID-19, enters human cells by attaching to ACE2 and utilizing TMPRSS2. Drugs that block ACE2 or inhibit the enzyme could help treat the coronavirus, but only during early infection. As the infection progresses, SARS-CoV-2 becomes engulfed in human cells, reducing the number of ACE2 receptors on a cell and leading to an increase of angiotensin II in the blood. Angiotensin II triggers an inflammatory pathway, providing a positive feedback cycle, named IL-6 amplifier, resulting in excessive immune activation and the cytokine storm associated with severe COVID-19.
The COVID-19 pandemic has had a significant effect on our perceptions of facemask wearers. Those who wore facemasks were considered healthier and more attractive than those without masks, a new study reports.