Researchers identified 21 proteins that specifically bind to a protein called ataxin-1. Twelve of these proteins enhance the misfolding of ataxin-1 and thus promote the formation of harmful protein aggregate structures, whereas nine of them prevent the misfolding.
Researchers are tracking the cause of premature neuron aging in Parkinson's patients with a defective DJ-1 gene.
By altering DON, an anti-cancer drug cultivated from bacteria originally found in Peruvian soil over 70 years ago, scientists believe they have made a safer and more tolerable form of the drug.
Researchers use iPSCs to create a disease in a dish model of Huntington's disease in transgenic nonhuman primates.
Researchers reveal how a repeating nucleotide sequence in the gene for a mutant protein may trigger Huntington's disease.
Researchers discover a novel factor which suppresses misfolding and aggregation of the huntingtin protein.
The key to performance and motivation lies within the ratio of glutamine and glutamate in the nucleus accumbens. The ratio of glutamine to glutamate relates specifically to stamina.
Researchers have developed a new model of mitochondrial epilepsy which captures specific features observed in patients. The new model may help provide better therapies and treatments for the condition.
A study of the Xhosa, an ancestral African population, sheds light on the genetic origins of schizophrenia.
Researchers find a single gene which encodes two separate proteins from the same sequence of messenger RNA. The finding could provide new strategies for treating SCA6.
A new study reports a potential new treatment for seizures which often occur in children with genetic metabolic disorders and people with liver failure.
Researchers have identified a reduced exchange of glutamine between astrocytes and neurons in a new Huntington's disease study.
