Researchers identified 21 proteins that specifically bind to a protein called ataxin-1. Twelve of these proteins enhance the misfolding of ataxin-1 and thus promote the formation of harmful protein aggregate structures, whereas nine of them prevent the misfolding.
Researchers find a single gene which encodes two separate proteins from the same sequence of messenger RNA. The finding could provide new strategies for treating SCA6.
A new study reports a potential new treatment for seizures which often occur in children with genetic metabolic disorders and people with liver failure.
Researchers use iPSCs to create a disease in a dish model of Huntington's disease in transgenic nonhuman primates.
Researchers discover a novel factor which suppresses misfolding and aggregation of the huntingtin protein.
Researchers report some proteins turn into liquid droplets on their way to becoming the toxic solids implicated in some neurodegenerative disorders.
Researchers are tracking the cause of premature neuron aging in Parkinson's patients with a defective DJ-1 gene.
By altering DON, an anti-cancer drug cultivated from bacteria originally found in Peruvian soil over 70 years ago, scientists believe they have made a safer and more tolerable form of the drug.
Researchers reveal how a repeating nucleotide sequence in the gene for a mutant protein may trigger Huntington's disease.
Summary: Researchers document not only the behavioral and cognitive effects of a single exercise session, but also the neurochemical and...
Researchers have identified a reduced exchange of glutamine between astrocytes and neurons in a new Huntington's disease study.
A new study, which involved a small sample of former professional athletes, found no evidence of early onset dementia.
