glioblastoma multiforme

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glioblastoma multiforme

Brain Cancer Featured Neurology Neuroscience

·August 27, 2019·4 min read

Researchers take aim at circadian clock in deadly brain cancer

Glioblastoma stem cells' circadian clocks ramp up the cells' metabolism, making them stronger, more resistant to treatment, and able to divide and multiply more rapidly. By targeting the stem cells with a small molecule drug, researchers found mice models lived longer and their tumors shrank.

Brain Cancer Featured Neurology Neuroscience Psychology

·May 1, 2020·3 min read

Schizophrenia drug combined with radiation shows promise in treating deadly brain tumors

Trifluoperazine, a dopamine receptor antagonist commonly prescribed for schizophrenia, used in combination with radiation therapy delays the growth of glioblastoma brain tumors and prolongs survival for brain cancer.

This is a drawing of a brain in a castle

Brain Cancer Featured Genetics Neurology Neuroscience

·January 15, 2020·3 min read

Scientists breach brain barriers to attack tumors

Introducing VEGF-C into the cerebrospinal fluid of mouse models of glioblastoma, researchers noted increased levels of T cell response to the cancerous tumors. When combined with immune system checkpoint inhibitors, the VEGF-C treatment significantly extended the life span of the mice with glioblastoma brain cancer.

This shows macrophages in GBM tissue samples

Brain Cancer Featured Neurology Neuroscience

·June 25, 2019·4 min read

Scientists track brain tumor turncoats with advanced imaging

Advanced imaging techniques visualize macrophages in brain tumors in mouse models of glioblastoma.

Brain Cancer Featured Genetics Neurology Open Neuroscience Articles

·January 2, 2019·7 min read

Sex Differences Identified in Glioblastoma Brain Cancer

A new study reveals distinct molecular differences in signatures of glioblastoma brain cancer between men and women. Researchers report current treatments for the brain cancer are more effective in women than in men. The findings could help to tailor treatments aimed at the different sexes and improve survival.

Brain Cancer Featured Neurology

·November 21, 2016·2 min read

Smart Drug Targets The Deadliest Brain Cancer For Destruction

Researchers have developed a new drug that could help prolong the lives of people with glioblastoma brain cancer.

Brain Cancer Featured Genetics Neurology Neuroscience

·June 10, 2019·5 min read

Study finds macrophages’ pathway to nurture PTEN-deficient glioblastoma: Mouse study

PTEN deficiency drives an increased expression of LOX. LOX attracts macrophages which protect gliobastoma brain cancer cells and provide growth factor support for the tumor, a new mouse study reveals.

Brain Cancer Featured Genetics Neurology Neuroscience

·July 19, 2019·6 min read

Study hints at why an aggressive form of brain cancer is hard to treat

Genetics and microenvironment influence the frequency of glioblastoma cells. Researchers provide a new blueprint for glioblastoma, integrating the malignant cell programs, cancer cell plasticity, and modulation by genetic drivers. The findings shed light on why this form of cancer is so hard to treat effectively.

Brain Cancer Featured Genetics Neurology

·August 1, 2012·2 min read

Study Suggests New Treatment Target for Deadly Brain Tumors

“We identified a subset of brain tumor cells that are slower growing or remain at rest, and appear to be the source of cancer recurrence after standard therapy in which the drug temozolomide is given to stop the tumor’s growth,” said Dr. Luis Parada. “Current therapy targets fast-growing tumor cells but not those responsible for new tumors. To the best of our knowledge, this is the first identification of a cancer stem-like cell in a spontaneously forming tumor inside a mammal.”

Brain Cancer Featured Neurology

·August 24, 2012·3 min read

Survival Statistics Show Hard Fight When Malignant Brain Tumors Appear at Multiple Sites

When aggressive, malignant tumors appear in more than one location in the brain, patient survival tends to be significantly shorter than when the disease starts as a single tumor, even though patients in both groups undergo virtually identical treatments, according to research at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Research Institute.

Brain Cancer Featured Genetics Open Neuroscience Articles

·October 10, 2013·5 min read

The Cancer Genome Atlas Exposes More Secrets of Lethal Brain Tumor

Researchers delve deeply into the genomics of 599 GBM brain cancer cases to better target the disease.

Brain Cancer Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·January 25, 2019·4 min read

The Hitchhiker’s Guide to Defeating Glioblastoma

Researchers have developed a new approach that uses microRNA in combination with chemotherapy to help treat glioblastoma brain cancer. In preclinical models, the approach increases survival of the deadly brain cancer five fold.

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