Latest

glioblastoma

Brain Cancer Featured Genetics Neurology Neuroscience

·May 30, 2025·6 min read

Lab-Designed Peptide Targets Glioblastoma Stem Cells

A newly developed lab-designed molecule, JM2, may offer a promising therapy to combat glioblastoma recurrence by targeting the tumor’s most resilient cells. Researchers discovered that glioblastoma stem cells rely on the protein connexin 43’s interaction with microtubules—an interaction disrupted by JM2.

Brain Cancer Featured Neurology Neuroscience

·May 15, 2025·4 min read

Gabapentin Linked to Longer Survival in Glioblastoma Brain Cancer

A new study suggests that gabapentin, a widely used anti-seizure medication, may improve survival in patients with glioblastoma (GBM), the deadliest form of brain cancer. Researchers found that GBM patients taking gabapentin lived several months longer than those who did not, across two independent hospital datasets.

Brain Cancer Featured Genetics Neurology Neuroscience

·May 12, 2025·6 min read

Mapping the Cellular Secrets of Glioblastoma

Two landmark studies have mapped the complex cellular ecosystems of glioblastoma, the deadliest form of brain cancer, offering unprecedented insights into how its diverse cells evolve and resist treatment. Using single-cell RNA sequencing on over 430,000 cells from 59 patients, researchers identified three new glioblastoma cell states and classified tumors into three overarching cellular ecosystems.

Brain Cancer Featured Neurology Neuroscience

·May 9, 2025·3 min read

Glioblastoma Vaccine Trial Moves Forward

The phase 2B SURVIVE trial testing SurVaxM, a cancer vaccine for glioblastoma, will continue as planned following an interim analysis showing sufficient promise to proceed. SurVaxM, combined with standard treatments like surgery, radiation, and chemotherapy, aims to extend survival and improve quality of life for patients with this aggressive brain cancer.

Brain Cancer Featured Genetics Neurology Neuroscience

·April 22, 2025·6 min read

Spatial Gene Hubs Reveal Hidden Drivers of Brain Cancer

A new study reveals that the way DNA folds inside brain cells plays a critical role in glioblastoma, one of the deadliest forms of brain cancer. Researchers discovered that in cancer cells, genes cluster into 3D "hubs" that coordinate tumor-driving activity, even without mutations.

Autism Brain Cancer Featured Genetics Neuroscience

·January 9, 2025·8 min read

Youthful Brain Stem Cells Linked to Autism and Brain Cancer

Researchers have identified a unique stem cell in the young brain capable of maturing into multiple cell types, potentially explaining the origins of autism and glioblastoma. These stem cells show gene expression patterns that regulate early brain development and, when disrupted, could lead to neurological conditions.

Brain Cancer Featured Neurology Neuroscience

·December 12, 2024·8 min read

Glioblastoma Syncs With the Body’s Internal Clock

Glioblastoma, an aggressive brain cancer, syncs its internal clock to the host’s circadian rhythms, leveraging daily hormone cycles for growth. Blocking these signals slowed tumor progression in mice and revealed that the timing of treatments like dexamethasone (DEX) critically influences outcomes.

Brain Cancer Featured Neurology Neuroscience

·December 9, 2024·6 min read

Lab-Grown Tumor Models Mirror Glioblastoma Treatment Response

Glioblastoma organoids, lab-grown replicas of a patient’s tumor, accurately predict how the tumor responds to CAR T cell therapy. This breakthrough allows real-time testing of therapies, showing that responses in the organoid closely mirror those in the patient.

Brain Cancer Featured Neurology Neuroscience

·December 6, 2024·7 min read

Targeted Immune Cells Destroy Brain Tumors

Researchers have created a "molecular GPS" to guide immune cells directly to the brain, enabling precise targeting of tumors like glioblastoma. These cells use a unique protein code to navigate and attack cancer while sparing healthy tissue, offering a safer alternative to traditional treatments. In mice, this technology successfully cleared tumors, prevented recurrences, and reduced brain inflammation in models of multiple sclerosis.

Brain Cancer Featured Neurology Neuroscience

·November 12, 2024·5 min read

CAR T-Cell Therapy Recruits Brain’s Defenses Against Glioblastoma

Researchers have developed an innovative CAR T-cell therapy to combat glioblastoma, the most common malignant brain tumor in adults. This approach not only attacks tumor cells directly but also reprograms the tumor's microenvironment, enabling immune cells to fight the cancer rather than protect it.

This shows a doctor looking at brain scans.

Brain Cancer Featured Neurology Neuroscience

·November 7, 2024·4 min read

Novel Vaccine Targets Deadly Brain Tumors with Precision

A novel vaccine can mobilize the immune system to precisely target and attack cancerous brain tumors, specifically gliomas, one of the deadliest brain tumor types. This groundbreaking work demonstrates that the body’s immune system can be directed to target proteins with cancer-driving mutations in tumors, marking a significant advance in immunotherapy.

Brain Cancer Featured Neurology Neuroscience

·November 4, 2024·5 min read

New Cell Targets Offer Hope for Treating Glioblastoma

Researchers have identified potential drug targets in glioblastoma cancer stem cells, providing a new approach to treat this aggressive brain cancer. By analyzing stem cells derived from patient tumors, scientists found two primary cell subtypes responsible for tumor growth, each with unique vulnerabilities.