When T helper cells are absent in the brain, microglia remain suspended between the fetal and adult developmental state. Mice lacking brain T cells showed changes in behavior and defective synaptic pruning. The study reveals the critical role T cells play in the development of the brain.
Researchers have identified a range of psychiatric disorders, including schizophrenia and autism, that share physical characteristics at the molecular level. Specifically, the study identifies common patterns of neural gene expression. In addition, researchers note important differences in gene expression that distinguish the disorders.
Persistent inflammation may underlie HIV associated neurocognitive disorders in patients taking specific antiretroviral drugs, a new study reports.
Using only enzymes, researchers were able to change synapses between inhibitory and excitatory types.
A new study reveals that most of the specific genes long thought to be linked to intelligence probably have no bearing on one’s IQ. And it may be some time before researchers can identify intelligence’s specific genetic roots.
A new study reports teenage binge drinking can result in lasting epigenetic changes that alter the expression of BDNF-AS, a protein vital for the formation of neural connection in the amygdala.
Women who give birth to their last child later in life may have an edge when it comes to longevity. Those who gave birth later in life had longer telomeres, which are biomarkers for long-term health and longevity.
UCSF researchers have developed a new genetic risk factor test that takes into account more than 24 genetic variants, each of which are associated with a small risk of Alzheimer's disease. The researchers say the test is a better method to help identify preclinical Alzheimer's than testing for ApoE4 alone.