CYFIP1 plays a key role in the damaging effects of 15q11.2 deletion. When CYFIP1 is missing, myelin abnormalities occur. The findings shed light on how psychiatric disorders, such as schizophrenia and autism, may develop.
Researchers report dysfunctional mitophagy may contribute to the development of Alzheimer's disease. When mitophagy is improved, symptoms of Alzheimer's almost disappeared in animal models of the disease.
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Zolgensma, an FDA approved gene therapy, supplements the production of the SMN protein to improve motor neuron function in children with spinal muscular atrophy after just one dose.
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Oxytocin, a hormone commonly associated with love and bonding in humans, causes starfish to turn their stomachs inside-out to feed. The findings provide vital new evidence for the evolutionary role of oxytocin and vasopressin neuropeptides as regulators of feeding in animals.
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Brain organoids, or mini-brains, created from human stem cells appear to develop in much the same way as a human brain. The organoids follow an internal clock that guides their maturation in sync with the timeline for human brain development.
Researchers report they have successfully developed 'mini-brains' made up of the many neurons and cells in the human brain. The mini brains could allow for better research and reduce the need for animal testing.
Researchers have identified four new genes that act independently as risk factors for multiple sclerosis.
Researchers establish SCN3A genetic mutations cause infantile epileptic encephalopathy.
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Despite growing evidence linking genetics to some criminal behavior, researchers report using genetic evidence is a court room is likely not to be an effective tool in persuading juries that a defendant is less culpable for their actions.
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Researchers have developed nanowires that can record the electrical activity of neurons in fine detail. The technology will allow for better investigation as to how the brain works.
Decreasing the amount of Reelin significantly protected against disease symptoms and promoted recovery in symptomatic animal models of multiple sclerosis. Reelin levels appear to correlate with MS severity and stages. Researchers report lowering levels of the protein could be a potential avenue of treatment for the autoimmune disorder.
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MicroRNA-132 regulates neurogenesis in the hippocampus, according to both mouse and human tissue studies. Restoring levels of microRNA-132 in mouse models of Alzheimer's disease reduces neurogenetic deficits and restores cognitive abilities, researchers say.