Researchers have created an atlas representing changes in the levels of RNA made in different cell types in the ear following noise-induced hearing loss. They also discovered certain FDA-approved medications for diabetes and other disorders may protect against noise-related hearing loss.
Opioid use disorder affects genes associated with proinflammatory immune molecule encoding and genes associated with remodeling the extracellular matrix, suggesting the connection between neurons may be altered as a result of opioid use. Additionally, those with OUD have higher levels of microglia in the brain.
Alterations in long-term social behavior and gene expression were observed in the offspring of mice exposed to pain-killing opioids during pregnancy.
Chronic cocaine use alters the epigenetic profile of the FosB gene in the hippocampus. These alterations are required for cocaine-dependent gene expression and cocaine environment associations. Modification of hippocampal FosB results in a condition critical for cocaine-related learning.
Researchers report the CPG2 protein is significantly decreased in the brains of people with bipolar disorder and mutations in the SYNE1 gene undermines the expression of CPG2. The study shows how a set of genetic differences in those with bipolar disorder can lead to specific psychological dysfunction in synapses in the brain. The findings could help improve diagnosis of the disorder and help develop new treatments for BD.
Researchers report alcohol hijacks a conserved memory pathway in the brain and alters protein expressed in neurons, forming craving that fuel addiction.
Researchers report just one night of sleep loss can have a tissue specific impact on metabolism and the regulation of gene expression. The study could explain why those who suffer chronic sleep loss or work shifts are at greater risk of obesity and type 2 diabetes.
Researchers report our inner thoughts and interpretations of our experiences have consequences for both physical and mental health.