Brain CancerFeaturedNeurologyNeuroscience·May 15, 2025·4 min readGabapentin Linked to Longer Survival in Glioblastoma Brain CancerA new study suggests that gabapentin, a widely used anti-seizure medication, may improve survival in patients with glioblastoma (GBM), the deadliest form of brain cancer. Researchers found that GBM patients taking gabapentin lived several months longer than those who did not, across two independent hospital datasets.Read More
Brain CancerFeaturedGeneticsNeurologyNeuroscience·May 12, 2025·6 min readMapping the Cellular Secrets of GlioblastomaTwo landmark studies have mapped the complex cellular ecosystems of glioblastoma, the deadliest form of brain cancer, offering unprecedented insights into how its diverse cells evolve and resist treatment. Using single-cell RNA sequencing on over 430,000 cells from 59 patients, researchers identified three new glioblastoma cell states and classified tumors into three overarching cellular ecosystems.Read More
Brain CancerFeaturedNeurologyNeuroscience·May 9, 2025·3 min readGlioblastoma Vaccine Trial Moves ForwardThe phase 2B SURVIVE trial testing SurVaxM, a cancer vaccine for glioblastoma, will continue as planned following an interim analysis showing sufficient promise to proceed. SurVaxM, combined with standard treatments like surgery, radiation, and chemotherapy, aims to extend survival and improve quality of life for patients with this aggressive brain cancer.Read More
Brain CancerFeaturedGeneticsNeurologyNeuroscience·April 22, 2025·6 min readSpatial Gene Hubs Reveal Hidden Drivers of Brain CancerA new study reveals that the way DNA folds inside brain cells plays a critical role in glioblastoma, one of the deadliest forms of brain cancer. Researchers discovered that in cancer cells, genes cluster into 3D "hubs" that coordinate tumor-driving activity, even without mutations.Read More
Brain CancerFeaturedNeurologyNeuroscience·December 9, 2024·6 min readLab-Grown Tumor Models Mirror Glioblastoma Treatment ResponseGlioblastoma organoids, lab-grown replicas of a patient’s tumor, accurately predict how the tumor responds to CAR T cell therapy. This breakthrough allows real-time testing of therapies, showing that responses in the organoid closely mirror those in the patient.Read More
Brain CancerFeaturedNeurologyNeuroscience·June 6, 2024·6 min readNew Hope for Treating Brain Cancer with UltrasoundResearchers used ultrasound to penetrate the blood-brain barrier, delivering a chemotherapy and immunotherapy drug combo to treat glioblastoma. This innovative approach boosted the immune system's recognition of cancer cells, showing promise for a new treatment method.Read More
Brain CancerFeaturedNeurologyNeuroscience·April 14, 2024·5 min readRevolutionizing Glioblastoma TreatmentResearchers demonstrated significant initial success using CAR-T therapy for glioblastoma, a notoriously deadly brain cancer. They detailed the outcomes of the first three patients in a Phase 1 clinical trial who experienced dramatic tumor reductions shortly after treatment.Read More
Brain CancerFeaturedNeurologyNeuroscience·October 26, 2023·3 min readBrain’s Fluid Shield May Dim Cancer Treatments: Old Drug Offers HopeCerebrospinal fluid, our brain's protective liquid, may be making brain cancers like glioblastoma more resistant to treatments. These findings indicate that when tumor cells are exposed to this fluid, they alter identity, resisting radiation and common medications.Read More
Brain CancerFeaturedNeurologyNeuroscience·July 3, 2023·4 min readAncient Virus Awakening: Hidden Culprit in Glioblastoma Brain Cancer AggressivenessThe reactivation of a dormant retrovirus, HML-2, may contribute to the aggressiveness of glioblastoma, a type of brain tumor. Researchers discovered that the virus influences the stem-cell state of the tumors, thereby promoting a more resistant form of cancer.Read More
Brain CancerFeaturedNeurologyNeuroscience·February 27, 2023·5 min readBlood Test for Brain Cancer May Be on HorizonA new blood-based test to screen for biomarkers of glioblastoma brain cancer has been developed by researchers at Penn State. The test looks for elevated levels of IL13Rα2, an antigen receptor that is derived from glioblastoma tumors.Read More
Brain CancerFeaturedGeneticsNeuroscience·January 21, 2023·2 min readProtein Movement Reveals Brain Tumor’s Weak SpotIn glioblastoma brain cancer, EGFR (HER1) genetic mutations lead to a movement of a large part of the extracellular region of the protein. This activates the intracellular area in a particular way that drives glioblastoma tumor development.Read More
Brain CancerFeaturedNeuroscience·January 16, 2023·3 min readUsing Machine Learning to Predict Brain Tumor ProgressionCombining machine learning technology with neuroimaging data, clinicians will be better able to fully analyze a patient's glioblastoma brain tumor and predict cancer progression.Read More
