Findings reveal the molecular mechanism for acetylcholine in learning and memory.
In mice, protein lactylation occurs in neurons and is correlated with lactate levels. Protein lactylation is enhanced by neural excitation and social stress. Researchers found social stress specifically enhances lysine lactylation of histone H1 proteins.
Researchers discover imbalanced pH and lactate levels in the brains of mouse models of schizophrenia, ASD and bipolar disorder. They believe the imbalances could reflect an underlying pathophysiology to some psychiatric disorders.