According to new research, in Alzheimer's patients, lysosomes lack the ability to perform their job correctly.
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A new machine learning algorithm is able to automatically able to distinguish between different patterns of progression in patients with a range of different dementias. The algorithm could enable to identify which treatments are most suited to individual patients.
Researchers have identified the location of dysfunctional brain networks that lead to impaired sentence production and word-finding in primary progressive aphasia (PPA). PPA can occur in those with neurodegenerative diseases, such as frontotemporal dementia and Alzheimer's disease. Mapping the networks allows clinicians to apply non-invasive brain stimulation to potentially improve speech in those with PPA.
Researchers have engineered a vaccine using virus-like particles that target Tau tangles in mouse models of Alzheimer's disease. Following the administration of the vaccine, the mice developed antibodies that cleared tau proteins, with the response lasting for a month. The mice also showed improvements in memory based tests and had less brain shrinkage than their peers who did not receive the vaccine. This suggests the vaccine prevented apoptosis. Researchers hope to move the vaccine to human clinical trials in the future.
Researchers believe many patients showing signs of dementia are being too quickly diagnose with Alzheimer's disease, when they may actually be suffering from frontotemporal dementia, thus delaying appropriate treatment.
New research supports the idea that a malfunction of the TDP-43 protein plays a decisive role in the development of ALS and FTD.
Moral emotions are significantly more impaired than emotions without moral content in those with frontotemporal dementia (FTD). By contrast, those with Alzheimer's disease exhibit similar performance in both moral and extra-moral emotions as healthy subjects. The findings provide a novel biomarker for the diagnosis of FTD.
For families of those with Alzheimer's disease, it's the changes in behavior and not loss of memory which makes those close say the patient isn't the same person any more.
Researchers report they have identified two regions of a mouse brain where a gene implicated in ALS is expressed.
Researchers believe a newly discovered mechanism may contribute to cell death in people suffering from ALS and dementia.