Using CRISPR, researchers have identified a new set of genes that may be implicated in both ALS and frontotemporal dementia.
Researchers report a new compound could help prevent and may even reverse some of the brain injury caused by the Tau protein in dementia.
Researchers recreated the damage seen in frontotemporal dementia in brain organoid models. The study reveals an experimental drug designed to treat Crohn's disease may help prevent neuron death associated with FTD.
A new study reveals many inhibitory neurons are lost in early phases of ALS and FTD development. The findings show a contrast to other neurodegenerative diseases where excitatory neurons are lost early in the disorders.
Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.
Researchers report neurodegeneration associated with frontotemporal dementia could span from a reduced trophic support for neurons.
According to researchers, FTD may be triggered by a defect in microglia.