Insulin binding receptors are predominantly located in the microvessels within the blood-brain barrier. In patients with Alzheimer's, the abundance of these receptors is decreased. This decrease could lead to the loss of insulin response in the Alzheimer's brain.
Vascular cell loss results in neuron loss, researchers report. However, pericytes secrete a substance that helps protect neurons, even when vascular cell degeneration begins to occur.
Exposure to everyday stressors may result in impairments in endothelial function for patients with major depressive disorder. The findings reveal a possible reason for the association between stress, depression and an increased risk of cardiovascular disease.
Researchers discover key elements associated with tumor cells binding to blood vessels. The findings could help develop new treatments to halt the development of brain tumors.
According to researchers, bone marrow stem cell transplants helped repair damage to the blood spinal cord barrier in mouse models of ALS. This helped improve motor functions and nervous system conditions.
According to researchers, a population of cells that help protect the brain from disease are not immune cells, but endothelial cells.
Mini-brains that are able to grow blood vessels are paramount for future investigation of neurological disorders, researchers report.
Researchers successfully grew adult human neurons from tissue donated from surgery patients. The researchers were able to identify at least 5 brain cell types and the potential proteins each cell could make.
A new blood-brain barrier on a chip system is being used to study neuroinflammation, researchers report.