A new study reveals how dangerous inflammations in the brain are caused during the aging process. Researchers say failure with the CB1 to control activity of immune cells may result in chronic neuroinflammation. They say it may be possible to break this vicious cycle in the future with drugs that contain THC, which is a powerful CB1 receptor activator.
Researchers shed light on the endocannabinoid system and report how cannabis is helping to provide relief to many with medical problems.
Cannabis consumption during pregnancy is associated with a slightly increased risk of a child developing psychosis at age ten. The findings also shed new light on the role endocannabinoids play in neurodevelopment.
The secretory pathway delivery of cannabinoid type 1 receptor is axonally based, and surface expressed CB1R is more stable in axons than dendrites.
While endocannabinoids have been reported to play a role in anti-inflammation in some areas of the brain, a new study reveals they may cause inflammation in the cerebellum.
Fatty acid amide hydrolase (FAAH) inhibitors, a form of medication that boosts endocannabinoids, may be helpful in the treatment of PTSD. FAAH inhibition can improve the recall of fear extinction memories. The drugs could also help treat stress and other psychological disorders.
When pregnant women consume diets high in polyunsaturated omega-6 fatty acids, an excess of endocannabinoids is produced which overloads the fetus, and impairs healthy brain development.